Optimization of extraction condition for supercritical carbon dioxide (SC-CO2) extraction of strobhilantes crispus (pecah kaca) leaves by response surface methodology
Supercritical carbon dioxide (SC-CO2) extraction was used to obtain the bioactive flavonoid compounds of Strobilanthes crispus (Pecah Kaca). Process variables namely pressure, temperature and co-solvent flow rate were studied for optimization of the extraction yield and bioactive flavonoid compound...
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my.utm.409542017-08-22T08:13:26Z http://eprints.utm.my/id/eprint/40954/ Optimization of extraction condition for supercritical carbon dioxide (SC-CO2) extraction of strobhilantes crispus (pecah kaca) leaves by response surface methodology Md. Salleh, Liza Abdul Rahman, Russly Selamat, Jinap Hamid, Azizah Md. Zaidul, I. S. Q Science Supercritical carbon dioxide (SC-CO2) extraction was used to obtain the bioactive flavonoid compounds of Strobilanthes crispus (Pecah Kaca). Process variables namely pressure, temperature and co-solvent flow rate were studied for optimization of the extraction yield and bioactive flavonoid compound of S. crispus by response surface methodology following a Box Behnken design of experiments. HPLC was performed to determine the major bioactive flavonoid compounds from S. crispus. The optimum value of yield extraction (6.55%) was obtained at pressure 200 bar, 50°C temperature and co-solvent flow rate of 5 g/min. Under the optimum conditions, eight flavonoid compounds were identified namely (+)-catechin, (-) epicatechin, rutin, myricetin, luteolin, apigenin, naringenin and kaempferol. The experimental extraction yield is in good agreement with the predicted one. The response surface methodology used in this study was able to predict the optimal extraction conditions for the extraction yield of bioactive flavonoid compounds from S. crispus leaves extract. 2013 Article PeerReviewed Md. Salleh, Liza and Abdul Rahman, Russly and Selamat, Jinap and Hamid, Azizah and Md. Zaidul, I. S. (2013) Optimization of extraction condition for supercritical carbon dioxide (SC-CO2) extraction of strobhilantes crispus (pecah kaca) leaves by response surface methodology. Journal of Food Processing and Technology, 4 (1). pp. 1-6. ISSN 2157-7110 |
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Q Science Md. Salleh, Liza Abdul Rahman, Russly Selamat, Jinap Hamid, Azizah Md. Zaidul, I. S. Optimization of extraction condition for supercritical carbon dioxide (SC-CO2) extraction of strobhilantes crispus (pecah kaca) leaves by response surface methodology |
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Supercritical carbon dioxide (SC-CO2) extraction was used to obtain the bioactive flavonoid compounds of Strobilanthes crispus (Pecah Kaca). Process variables namely pressure, temperature and co-solvent flow rate were studied for optimization of the extraction yield and bioactive flavonoid compound of S. crispus by response surface methodology following a Box Behnken design of experiments. HPLC was performed to determine the major bioactive flavonoid compounds from S. crispus. The optimum value of yield extraction (6.55%) was obtained at pressure 200 bar, 50°C temperature and co-solvent flow rate of 5 g/min. Under the optimum conditions, eight flavonoid compounds were identified namely (+)-catechin, (-) epicatechin, rutin, myricetin, luteolin, apigenin, naringenin and kaempferol. The experimental extraction yield is in good agreement with the predicted one. The response surface methodology used in this study was able to predict the optimal extraction conditions for the extraction yield of bioactive flavonoid compounds from S. crispus leaves extract. |
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Article |
author |
Md. Salleh, Liza Abdul Rahman, Russly Selamat, Jinap Hamid, Azizah Md. Zaidul, I. S. |
author_facet |
Md. Salleh, Liza Abdul Rahman, Russly Selamat, Jinap Hamid, Azizah Md. Zaidul, I. S. |
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Md. Salleh, Liza |
title |
Optimization of extraction condition for supercritical carbon dioxide (SC-CO2) extraction of strobhilantes crispus (pecah kaca) leaves by response surface methodology |
title_short |
Optimization of extraction condition for supercritical carbon dioxide (SC-CO2) extraction of strobhilantes crispus (pecah kaca) leaves by response surface methodology |
title_full |
Optimization of extraction condition for supercritical carbon dioxide (SC-CO2) extraction of strobhilantes crispus (pecah kaca) leaves by response surface methodology |
title_fullStr |
Optimization of extraction condition for supercritical carbon dioxide (SC-CO2) extraction of strobhilantes crispus (pecah kaca) leaves by response surface methodology |
title_full_unstemmed |
Optimization of extraction condition for supercritical carbon dioxide (SC-CO2) extraction of strobhilantes crispus (pecah kaca) leaves by response surface methodology |
title_sort |
optimization of extraction condition for supercritical carbon dioxide (sc-co2) extraction of strobhilantes crispus (pecah kaca) leaves by response surface methodology |
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2013 |
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http://eprints.utm.my/id/eprint/40954/ |
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