Effects of irregular cerebrospinal fluid production rate in human brain ventricular system
Hydrocephalus is an abnormal accumulation of fluid in the ventricles and cavities in the brain. It occurs when the cerebrospinal fluid (CSF) flow or absorption is blocked or when excessive CSF is secreted. The excessive accumulation of CSF results in an abnormal widening of the ventricles. This wide...
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my.utm.357552017-02-02T05:29:26Z http://eprints.utm.my/id/eprint/35755/ Effects of irregular cerebrospinal fluid production rate in human brain ventricular system Hadzri, Edi Azali Shamsudin, Amir Hamzah Osman, Kahar Abdul Kadir, Mohammed Rafiq Abdul Aziz, Azian TJ Mechanical engineering and machinery Hydrocephalus is an abnormal accumulation of fluid in the ventricles and cavities in the brain. It occurs when the cerebrospinal fluid (CSF) flow or absorption is blocked or when excessive CSF is secreted. The excessive accumulation of CSF results in an abnormal widening of the ventricles. This widening creates potentially harmful pressure on the tissues of the brain. In this study, flow analysis of CSF was conducted on a three-dimensional model of the third ventricle and aqueduct of Sylvius, derived from MRI scans. CSF was modeled as Newtonian Fluid and its flow through the region of interest (ROI) was done using EFD. Lab software. Different steady flow rates through the Foramen of Monro, classified by normal and hydrocephalus cases, were modeled to investigate its effects. The results show that, for normal and hydrocephalus cases, the pressure drop of CSF flow across the third ventricle was observed to be linearly proportionally to the production rate increment. In conclusion, flow rates that cause pressure drop of 5 Pa was found to be the threshold for the initial sign of hydrocephalus. American Institute of Physics 2012 Book Section PeerReviewed Hadzri, Edi Azali and Shamsudin, Amir Hamzah and Osman, Kahar and Abdul Kadir, Mohammed Rafiq and Abdul Aziz, Azian (2012) Effects of irregular cerebrospinal fluid production rate in human brain ventricular system. In: 4Th International Meeting of Advances in Thermofluids (Imat 2011), Pt 1 And 2. American Institute of Physics, Maryland, New York, pp. 659-664. ISBN 978-073541032-9 http://dx.doi.org/10.1063/1.4704275 DOI:10.1063/1.4704275 |
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TJ Mechanical engineering and machinery Hadzri, Edi Azali Shamsudin, Amir Hamzah Osman, Kahar Abdul Kadir, Mohammed Rafiq Abdul Aziz, Azian Effects of irregular cerebrospinal fluid production rate in human brain ventricular system |
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Hydrocephalus is an abnormal accumulation of fluid in the ventricles and cavities in the brain. It occurs when the cerebrospinal fluid (CSF) flow or absorption is blocked or when excessive CSF is secreted. The excessive accumulation of CSF results in an abnormal widening of the ventricles. This widening creates potentially harmful pressure on the tissues of the brain. In this study, flow analysis of CSF was conducted on a three-dimensional model of the third ventricle and aqueduct of Sylvius, derived from MRI scans. CSF was modeled as Newtonian Fluid and its flow through the region of interest (ROI) was done using EFD. Lab software. Different steady flow rates through the Foramen of Monro, classified by normal and hydrocephalus cases, were modeled to investigate its effects. The results show that, for normal and hydrocephalus cases, the pressure drop of CSF flow across the third ventricle was observed to be linearly proportionally to the production rate increment. In conclusion, flow rates that cause pressure drop of 5 Pa was found to be the threshold for the initial sign of hydrocephalus. |
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Book Section |
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Hadzri, Edi Azali Shamsudin, Amir Hamzah Osman, Kahar Abdul Kadir, Mohammed Rafiq Abdul Aziz, Azian |
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Hadzri, Edi Azali Shamsudin, Amir Hamzah Osman, Kahar Abdul Kadir, Mohammed Rafiq Abdul Aziz, Azian |
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Hadzri, Edi Azali |
title |
Effects of irregular cerebrospinal fluid production rate in human brain ventricular system |
title_short |
Effects of irregular cerebrospinal fluid production rate in human brain ventricular system |
title_full |
Effects of irregular cerebrospinal fluid production rate in human brain ventricular system |
title_fullStr |
Effects of irregular cerebrospinal fluid production rate in human brain ventricular system |
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Effects of irregular cerebrospinal fluid production rate in human brain ventricular system |
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effects of irregular cerebrospinal fluid production rate in human brain ventricular system |
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American Institute of Physics |
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2012 |
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http://eprints.utm.my/id/eprint/35755/ http://dx.doi.org/10.1063/1.4704275 |
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