Metabolic pathway extraction using combined probabilistic models
Extracting metabolic pathway from microarray gene expression data that dictates a specific biological response is currently one of the important disciplines in system biology research. However due to the complexity of the global metabolic network and the importance to maintain the biological structu...
Saved in:
Main Authors: | , |
---|---|
Format: | Article |
Published: |
Science & Engineering Research Support Society
2012
|
Subjects: | |
Online Access: | http://eprints.utm.my/id/eprint/32912/ http://www.riss.kr/link?id=A99874800 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
my.utm.32912 |
---|---|
record_format |
eprints |
spelling |
my.utm.329122019-03-05T02:09:27Z http://eprints.utm.my/id/eprint/32912/ Metabolic pathway extraction using combined probabilistic models Mohamed Salleh, Abdul Hakim Mohammad, Mohd. Saberi QA75 Electronic computers. Computer science QA76 Computer software Extracting metabolic pathway from microarray gene expression data that dictates a specific biological response is currently one of the important disciplines in system biology research. However due to the complexity of the global metabolic network and the importance to maintain the biological structure, this has become a greater challenge. Previous methods have successfully identified those pathways but without concerning the genetic effect and relationship of the genes, representation of the underlying structure is not precise and cannot be justified to be significant biologically. In this article, probabilistic models that are capable of identifying the significant pathways through metabolic networks related to a specific biological response are implemented. This article utilized combination of two probabilistic models to address the limitations of previous methods with the annotation to pathway database to ensure the pathway is biologically plausible. Science & Engineering Research Support Society 2012-06 Article PeerReviewed Mohamed Salleh, Abdul Hakim and Mohammad, Mohd. Saberi (2012) Metabolic pathway extraction using combined probabilistic models. International Journal of Bio-Science and Bio-Technology, 4 (2). pp. 1-10. ISSN 2233-7849 http://www.riss.kr/link?id=A99874800 |
institution |
Universiti Teknologi Malaysia |
building |
UTM Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
Universiti Teknologi Malaysia |
content_source |
UTM Institutional Repository |
url_provider |
http://eprints.utm.my/ |
topic |
QA75 Electronic computers. Computer science QA76 Computer software |
spellingShingle |
QA75 Electronic computers. Computer science QA76 Computer software Mohamed Salleh, Abdul Hakim Mohammad, Mohd. Saberi Metabolic pathway extraction using combined probabilistic models |
description |
Extracting metabolic pathway from microarray gene expression data that dictates a specific biological response is currently one of the important disciplines in system biology research. However due to the complexity of the global metabolic network and the importance to maintain the biological structure, this has become a greater challenge. Previous methods have successfully identified those pathways but without concerning the genetic effect and relationship of the genes, representation of the underlying structure is not precise and cannot be justified to be significant biologically. In this article, probabilistic models that are capable of identifying the significant pathways through metabolic networks related to a specific biological response are implemented. This article utilized combination of two probabilistic models to address the limitations of previous methods with the annotation to pathway database to ensure the pathway is biologically plausible. |
format |
Article |
author |
Mohamed Salleh, Abdul Hakim Mohammad, Mohd. Saberi |
author_facet |
Mohamed Salleh, Abdul Hakim Mohammad, Mohd. Saberi |
author_sort |
Mohamed Salleh, Abdul Hakim |
title |
Metabolic pathway extraction using combined probabilistic models |
title_short |
Metabolic pathway extraction using combined probabilistic models |
title_full |
Metabolic pathway extraction using combined probabilistic models |
title_fullStr |
Metabolic pathway extraction using combined probabilistic models |
title_full_unstemmed |
Metabolic pathway extraction using combined probabilistic models |
title_sort |
metabolic pathway extraction using combined probabilistic models |
publisher |
Science & Engineering Research Support Society |
publishDate |
2012 |
url |
http://eprints.utm.my/id/eprint/32912/ http://www.riss.kr/link?id=A99874800 |
_version_ |
1643649176604508160 |
score |
13.160551 |