Group aggregating normalization method for the preprocessing of NMR-based metabolomic data

• Main Authors: Dong, J., Cheng, Kian Kai, Xu, J., Chen, Z., Griffin, J. L.
• Format: Article
• Published: Elsevier B.V. 2011
• Subjects: QD Chemistry
• Online Access: http://eprints.utm.my/id/eprint/29150/; http://dx.doi.org/10.1016/j.chemolab.2011.06.002

Data normalization plays a crucial role in metabolomics to take into account the inevitable variation in sample concentration and the efficiency of sample preparation procedure. The conventional methods such as constant sum normalization (CSN) and probabilistic quotient normalization (PQN) are widel...