Synthesis of cationic porphyrins as potential gene transfection carriers

• Main Authors: Kiew, Siaw Fui, Mohamed Zulkifli, Razauden, Bakar, Mohd. Bakri
• Format: Article
• Language: English
• Published: Ibnu Sina Institute for Fundamental Science Studies, Universiti Teknologi Malaysia 2012
• Subjects: Q Science (General); QM Human anatomy; R Medicine (General)
• Online Access: http://eprints.utm.my/id/eprint/29092/1/RazaudenMohamedZulkifli2012_SynthesisofCationicPorphyrins.pdf; http://eprints.utm.my/id/eprint/29092/; http://mjfas.ibnusina.utm.my/index.php/jfs/article/viewFile/303/243

Porphyrins are found having strong but reversible interaction with nucleic acid and thus can be used as complementary to other non-viral vectors in gene transfection delivery. Amphiphilic porphyrins with combination of hydrophobic and hydrophilic substituents along the peripheral of porphyrin macroc...