Metabolomic study of the LDL receptor null mouse fed a high-fat diet reveals profound perturbations in choline metabolism that are shared with ApoE null mice

• Main Authors: Kian Kai, Cheng, Benson, G. Martin, C. Grimsditch, David, G. Reid, David, C. Connor, Susan, L. Griffin, Julian
• Format: Article
• Language: English
• Published: The American Physiological Society 2010
• Subjects: QD Chemistry
• Online Access: http://eprints.utm.my/id/eprint/26274/1/ChengKianKai2010_MetabolomicStudyoftheLDLReceptorNull.pdf; http://eprints.utm.my/id/eprint/26274/; http://dx.doi.org/10.1152/physiolgenomics.00188.2009

Failure to express or expression of dysfunctional low-density lipoprotein receptors (LDLR) causes familial hypercholesterolemia in humans, a disease characterized by elevated blood cholesterol concentrations, xanthomas, and coronary heart disease, providing compelling evidence that high blood choles...