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Chiral separation of econazole using micellar electrokinetic chromatography with hydroxypropyl-gamma-cyclodextrin

The separation of enantiomers is one of the important fi elds of modern analytical chemistry, especially for agrochemical and pharmaceutical products because the stereochemistry has a signi fi cant in fl uence on the biological activities of compounds. Cyclodextrin-modi fi ed micellar electrokinetic...

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Main Authors: Ibrahim, W. A. W., Hermawan, Dadan, Sanagi, M. M.
Format: Article
Published: Elsevier B. V. 2010
Subjects:
Q Science (General)
Online Access:http://eprints.utm.my/id/eprint/22959/
http://dx.doi.org/10.1007/978-1-62703-263-6_22
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spelling my.utm.229592018-10-21T04:29:50Z http://eprints.utm.my/id/eprint/22959/ Chiral separation of econazole using micellar electrokinetic chromatography with hydroxypropyl-gamma-cyclodextrin Ibrahim, W. A. W. Hermawan, Dadan Sanagi, M. M. Q Science (General) The separation of enantiomers is one of the important fi elds of modern analytical chemistry, especially for agrochemical and pharmaceutical products because the stereochemistry has a signi fi cant in fl uence on the biological activities of compounds. Cyclodextrin-modi fi ed micellar electrokinetic chromatography (CD-MEKC) has become an important capillary electrophoresis mode for enantioseparations. Here, we describe an example of a CD-MEKC method using hydroxypropyl- ? -cyclodextrin as chiral selector and sodium dodecyl sulfate as micellar solution for enantioseparation of triazole fungicides and the drug econazole. Elsevier B. V. 2010-12 Article PeerReviewed Ibrahim, W. A. W. and Hermawan, Dadan and Sanagi, M. M. (2010) Chiral separation of econazole using micellar electrokinetic chromatography with hydroxypropyl-gamma-cyclodextrin. Journal of Pharmaceutical and Biomedical Analysis, 53 (5). 1244 - 1249. http://dx.doi.org/10.1007/978-1-62703-263-6_22 DOI:10.1007/978-1-62703-263-6_22
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic Q Science (General)
spellingShingle Q Science (General)
Ibrahim, W. A. W.
Hermawan, Dadan
Sanagi, M. M.
Chiral separation of econazole using micellar electrokinetic chromatography with hydroxypropyl-gamma-cyclodextrin
description The separation of enantiomers is one of the important fi elds of modern analytical chemistry, especially for agrochemical and pharmaceutical products because the stereochemistry has a signi fi cant in fl uence on the biological activities of compounds. Cyclodextrin-modi fi ed micellar electrokinetic chromatography (CD-MEKC) has become an important capillary electrophoresis mode for enantioseparations. Here, we describe an example of a CD-MEKC method using hydroxypropyl- ? -cyclodextrin as chiral selector and sodium dodecyl sulfate as micellar solution for enantioseparation of triazole fungicides and the drug econazole.
format Article
author Ibrahim, W. A. W.
Hermawan, Dadan
Sanagi, M. M.
author_facet Ibrahim, W. A. W.
Hermawan, Dadan
Sanagi, M. M.
author_sort Ibrahim, W. A. W.
title Chiral separation of econazole using micellar electrokinetic chromatography with hydroxypropyl-gamma-cyclodextrin
title_short Chiral separation of econazole using micellar electrokinetic chromatography with hydroxypropyl-gamma-cyclodextrin
title_full Chiral separation of econazole using micellar electrokinetic chromatography with hydroxypropyl-gamma-cyclodextrin
title_fullStr Chiral separation of econazole using micellar electrokinetic chromatography with hydroxypropyl-gamma-cyclodextrin
title_full_unstemmed Chiral separation of econazole using micellar electrokinetic chromatography with hydroxypropyl-gamma-cyclodextrin
title_sort chiral separation of econazole using micellar electrokinetic chromatography with hydroxypropyl-gamma-cyclodextrin
publisher Elsevier B. V.
publishDate 2010
url http://eprints.utm.my/id/eprint/22959/
http://dx.doi.org/10.1007/978-1-62703-263-6_22
_version_ 1643647434965909504
score 13.2014675

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