Fuzzy C-means clustering for DNA computing readout method implemented on LightCycler system
In the previous work, a readout approach for the Hamiltonian Path Problem (HPP) in DNA computing, based on the real-time polymerase chain reaction (PCR) was proposed. Based on this approach, real-time amplification was performed with TaqMan probes, and the TaqMan detection mechanism was exploited fo...
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my.utm.125732011-06-09T08:07:55Z http://eprints.utm.my/id/eprint/12573/ Fuzzy C-means clustering for DNA computing readout method implemented on LightCycler system Saaid, M. F. M. Ibrahim, Zuwairie Khalid, Marzuki Sarmin, Nor Haniza Rose, John A. Q Science (General) QA Mathematics In the previous work, a readout approach for the Hamiltonian Path Problem (HPP) in DNA computing, based on the real-time polymerase chain reaction (PCR) was proposed. Based on this approach, real-time amplification was performed with TaqMan probes, and the TaqMan detection mechanism was exploited for the design and development of the readout approach. The readout approach consists of two steps: real-time amplification in vitro using TaqMan-based real-time PCR followed by information processing in silico to assess the results of real-time amplification, which in turn, enables extraction of the Hamiltonian path. However, the previous method used manual classification of two different output reactions of real-time PCR In this paper, the Fuzzy C-Means (FCM) clustering algorithm is used to automatically identify two different reactions in real-time PCR We show that the FCM clustering technique can be implemented for clustering the output results of the DNA computing readout method based on the LightCycler System. Society of Instrument And Control Engineers 2008 Book Section PeerReviewed Saaid, M. F. M. and Ibrahim, Zuwairie and Khalid, Marzuki and Sarmin, Nor Haniza and Rose, John A. (2008) Fuzzy C-means clustering for DNA computing readout method implemented on LightCycler system. In: Proceedings of the SICE Annual Conference. Society of Instrument And Control Engineers, Japan, 676 -681. ISBN 978-490776429-6 http://dx.doi.org/10.1109/SICE.2008.4654741 doi:10.1109/SICE.2008.4654741 |
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Q Science (General) QA Mathematics Saaid, M. F. M. Ibrahim, Zuwairie Khalid, Marzuki Sarmin, Nor Haniza Rose, John A. Fuzzy C-means clustering for DNA computing readout method implemented on LightCycler system |
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In the previous work, a readout approach for the Hamiltonian Path Problem (HPP) in DNA computing, based on the real-time polymerase chain reaction (PCR) was proposed. Based on this approach, real-time amplification was performed with TaqMan probes, and the TaqMan detection mechanism was exploited for the design and development of the readout approach. The readout approach consists of two steps: real-time amplification in vitro using TaqMan-based real-time PCR followed by information processing in silico to assess the results of real-time amplification, which in turn, enables extraction of the Hamiltonian path. However, the previous method used manual classification of two different output reactions of real-time PCR In this paper, the Fuzzy C-Means (FCM) clustering algorithm is used to automatically identify two different reactions in real-time PCR We show that the FCM clustering technique can be implemented for clustering the output results of the DNA computing readout method based on the LightCycler System. |
format |
Book Section |
author |
Saaid, M. F. M. Ibrahim, Zuwairie Khalid, Marzuki Sarmin, Nor Haniza Rose, John A. |
author_facet |
Saaid, M. F. M. Ibrahim, Zuwairie Khalid, Marzuki Sarmin, Nor Haniza Rose, John A. |
author_sort |
Saaid, M. F. M. |
title |
Fuzzy C-means clustering for DNA computing readout method implemented on LightCycler system |
title_short |
Fuzzy C-means clustering for DNA computing readout method implemented on LightCycler system |
title_full |
Fuzzy C-means clustering for DNA computing readout method implemented on LightCycler system |
title_fullStr |
Fuzzy C-means clustering for DNA computing readout method implemented on LightCycler system |
title_full_unstemmed |
Fuzzy C-means clustering for DNA computing readout method implemented on LightCycler system |
title_sort |
fuzzy c-means clustering for dna computing readout method implemented on lightcycler system |
publisher |
Society of Instrument And Control Engineers |
publishDate |
2008 |
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http://eprints.utm.my/id/eprint/12573/ http://dx.doi.org/10.1109/SICE.2008.4654741 |
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1643645987674128384 |
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13.160551 |