Validation calibration factor of single photon emission computed tomography for iodine-131 using non-spherical targeted volume.
Absolute quantification of Iodine-131 (131I) on Single Photon Emission Computed Tomography (SPECT) imaging is extremely necessary for the lesion dose per administrative differentiated thyroid cancer procedure. However, non-quantitative SPECT imaging makes determining the dose required for a tumour t...
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Online Access: | http://eprints.utm.my/106050/1/KaharOsman2023_ValidationCalibrationFactorofSinglePhotonEmission.pdf http://eprints.utm.my/106050/ http://dx.doi.org/10.37934/aram.110.1.7385 |
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my.utm.1060502024-05-29T06:53:47Z http://eprints.utm.my/106050/ Validation calibration factor of single photon emission computed tomography for iodine-131 using non-spherical targeted volume. Masud, Mohd. Akmal Ngali, Mohd. Zamani Othman, Siti Amira Taib, Ishkrizat Osman, Kahar Md. Salleh, Salihatun Md. Khudzari, Ahmad Zahran Ali, Nor Salita Chaichana, Anucha Q Science (General) Absolute quantification of Iodine-131 (131I) on Single Photon Emission Computed Tomography (SPECT) imaging is extremely necessary for the lesion dose per administrative differentiated thyroid cancer procedure. However, non-quantitative SPECT imaging makes determining the dose required for a tumour to be treated is challenging. This multi-vendor and multi-centre research use phantom measures to assess the quantitative accuracy and inter-system variability of various SPECT/CT systems. Hence, this study aims to determine the calibration factor (CF) for131I activity quantification using the National Electrical Manufacturer Association (NEMA) phantom uptake for the Philips BrightView XCT modality. The accuracy activity concentration for a non-spherical targeted volume is less than 15% compared to a spherical targeted volume (<9%). Furthermore, the CF has no significant difference in the value between the matrix sizes of 64×64, 128×128, and 256×256. Therefore, the gamma camera CF must be precisely determined to convert the reconstructed images' counts into activity values for quantitative imaging. However, the NEMA phantom with spherical geometrical is the standard tool for determining CF, the various geometrical shapes other than spherical should be considered for determining CF because the effect of photon distribution contribution is different for any different lesion geometrical. Semarak Ilmu Publishing 2023 Article PeerReviewed application/pdf en http://eprints.utm.my/106050/1/KaharOsman2023_ValidationCalibrationFactorofSinglePhotonEmission.pdf Masud, Mohd. Akmal and Ngali, Mohd. Zamani and Othman, Siti Amira and Taib, Ishkrizat and Osman, Kahar and Md. Salleh, Salihatun and Md. Khudzari, Ahmad Zahran and Ali, Nor Salita and Chaichana, Anucha (2023) Validation calibration factor of single photon emission computed tomography for iodine-131 using non-spherical targeted volume. Journal of Advanced Research in Applied Mechanics, 110 (1). pp. 73-85. ISSN 2289-7895 http://dx.doi.org/10.37934/aram.110.1.7385 DOI: 10.37934/aram.110.1.7385 |
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Q Science (General) Masud, Mohd. Akmal Ngali, Mohd. Zamani Othman, Siti Amira Taib, Ishkrizat Osman, Kahar Md. Salleh, Salihatun Md. Khudzari, Ahmad Zahran Ali, Nor Salita Chaichana, Anucha Validation calibration factor of single photon emission computed tomography for iodine-131 using non-spherical targeted volume. |
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Absolute quantification of Iodine-131 (131I) on Single Photon Emission Computed Tomography (SPECT) imaging is extremely necessary for the lesion dose per administrative differentiated thyroid cancer procedure. However, non-quantitative SPECT imaging makes determining the dose required for a tumour to be treated is challenging. This multi-vendor and multi-centre research use phantom measures to assess the quantitative accuracy and inter-system variability of various SPECT/CT systems. Hence, this study aims to determine the calibration factor (CF) for131I activity quantification using the National Electrical Manufacturer Association (NEMA) phantom uptake for the Philips BrightView XCT modality. The accuracy activity concentration for a non-spherical targeted volume is less than 15% compared to a spherical targeted volume (<9%). Furthermore, the CF has no significant difference in the value between the matrix sizes of 64×64, 128×128, and 256×256. Therefore, the gamma camera CF must be precisely determined to convert the reconstructed images' counts into activity values for quantitative imaging. However, the NEMA phantom with spherical geometrical is the standard tool for determining CF, the various geometrical shapes other than spherical should be considered for determining CF because the effect of photon distribution contribution is different for any different lesion geometrical. |
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Article |
author |
Masud, Mohd. Akmal Ngali, Mohd. Zamani Othman, Siti Amira Taib, Ishkrizat Osman, Kahar Md. Salleh, Salihatun Md. Khudzari, Ahmad Zahran Ali, Nor Salita Chaichana, Anucha |
author_facet |
Masud, Mohd. Akmal Ngali, Mohd. Zamani Othman, Siti Amira Taib, Ishkrizat Osman, Kahar Md. Salleh, Salihatun Md. Khudzari, Ahmad Zahran Ali, Nor Salita Chaichana, Anucha |
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Masud, Mohd. Akmal |
title |
Validation calibration factor of single photon emission computed tomography for iodine-131 using non-spherical targeted volume. |
title_short |
Validation calibration factor of single photon emission computed tomography for iodine-131 using non-spherical targeted volume. |
title_full |
Validation calibration factor of single photon emission computed tomography for iodine-131 using non-spherical targeted volume. |
title_fullStr |
Validation calibration factor of single photon emission computed tomography for iodine-131 using non-spherical targeted volume. |
title_full_unstemmed |
Validation calibration factor of single photon emission computed tomography for iodine-131 using non-spherical targeted volume. |
title_sort |
validation calibration factor of single photon emission computed tomography for iodine-131 using non-spherical targeted volume. |
publisher |
Semarak Ilmu Publishing |
publishDate |
2023 |
url |
http://eprints.utm.my/106050/1/KaharOsman2023_ValidationCalibrationFactorofSinglePhotonEmission.pdf http://eprints.utm.my/106050/ http://dx.doi.org/10.37934/aram.110.1.7385 |
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1800714791753351168 |
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13.18916 |