Lactic acid bacteria and their bacteriocins: new potential weapons in the fight against methicillin-resistant Staphylococcus aureus
Alternative solutions are eminently needed to combat the escalating number of infections caused by methicillin-resistant Staphylococcus aureus (MRSA). Bacteriocins produced by lactic acid bacteria are promising candidates for next-generation antibiotics. Studies have found that these stable and nont...
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2022
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my.utm.1042202024-01-18T00:28:51Z http://eprints.utm.my/104220/ Lactic acid bacteria and their bacteriocins: new potential weapons in the fight against methicillin-resistant Staphylococcus aureus Yaacob, Syariffah N. S. A. Wahab, Roswanira Misson, Mailin Sabullah, Mohd. K. Huyop, Fahrul M. Zin, Noraziah QD Chemistry Alternative solutions are eminently needed to combat the escalating number of infections caused by methicillin-resistant Staphylococcus aureus (MRSA). Bacteriocins produced by lactic acid bacteria are promising candidates for next-generation antibiotics. Studies have found that these stable and nontoxic ribosomally synthesized antimicrobial peptides exhibit significant potency against other bacteria, including antibiotic-resistant strains. Here the authors review previous studies on bacteriocins that have been effectively employed to manage MRSA infections. The authors' review focuses on the beneficial traits of bacteriocins for further application as templates for the design of novel drugs. Treatments that combine bacteriocins with other antimicrobials to combat pervasive MRSA infections are also highlighted. In short, future studies should focus on the pharmacodynamics and pharmacokinetics of bacteriocins-antimicrobials to understand their interactions, as this aspect would likely determine their efficacy in MRSA inhibition. Future Medicine Ltd. 2022 Article PeerReviewed Yaacob, Syariffah N. S. and A. Wahab, Roswanira and Misson, Mailin and Sabullah, Mohd. K. and Huyop, Fahrul and M. Zin, Noraziah (2022) Lactic acid bacteria and their bacteriocins: new potential weapons in the fight against methicillin-resistant Staphylococcus aureus. Future Microbiology, 17 (9). pp. 683-699. ISSN 1746-0913 http://dx.doi.org/10.2217/fmb-2021-0256 DOI : 10.2217/fmb-2021-0256 |
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QD Chemistry Yaacob, Syariffah N. S. A. Wahab, Roswanira Misson, Mailin Sabullah, Mohd. K. Huyop, Fahrul M. Zin, Noraziah Lactic acid bacteria and their bacteriocins: new potential weapons in the fight against methicillin-resistant Staphylococcus aureus |
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Alternative solutions are eminently needed to combat the escalating number of infections caused by methicillin-resistant Staphylococcus aureus (MRSA). Bacteriocins produced by lactic acid bacteria are promising candidates for next-generation antibiotics. Studies have found that these stable and nontoxic ribosomally synthesized antimicrobial peptides exhibit significant potency against other bacteria, including antibiotic-resistant strains. Here the authors review previous studies on bacteriocins that have been effectively employed to manage MRSA infections. The authors' review focuses on the beneficial traits of bacteriocins for further application as templates for the design of novel drugs. Treatments that combine bacteriocins with other antimicrobials to combat pervasive MRSA infections are also highlighted. In short, future studies should focus on the pharmacodynamics and pharmacokinetics of bacteriocins-antimicrobials to understand their interactions, as this aspect would likely determine their efficacy in MRSA inhibition. |
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Article |
author |
Yaacob, Syariffah N. S. A. Wahab, Roswanira Misson, Mailin Sabullah, Mohd. K. Huyop, Fahrul M. Zin, Noraziah |
author_facet |
Yaacob, Syariffah N. S. A. Wahab, Roswanira Misson, Mailin Sabullah, Mohd. K. Huyop, Fahrul M. Zin, Noraziah |
author_sort |
Yaacob, Syariffah N. S. |
title |
Lactic acid bacteria and their bacteriocins: new potential weapons in the fight against methicillin-resistant Staphylococcus aureus |
title_short |
Lactic acid bacteria and their bacteriocins: new potential weapons in the fight against methicillin-resistant Staphylococcus aureus |
title_full |
Lactic acid bacteria and their bacteriocins: new potential weapons in the fight against methicillin-resistant Staphylococcus aureus |
title_fullStr |
Lactic acid bacteria and their bacteriocins: new potential weapons in the fight against methicillin-resistant Staphylococcus aureus |
title_full_unstemmed |
Lactic acid bacteria and their bacteriocins: new potential weapons in the fight against methicillin-resistant Staphylococcus aureus |
title_sort |
lactic acid bacteria and their bacteriocins: new potential weapons in the fight against methicillin-resistant staphylococcus aureus |
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Future Medicine Ltd. |
publishDate |
2022 |
url |
http://eprints.utm.my/104220/ http://dx.doi.org/10.2217/fmb-2021-0256 |
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1789424395916148736 |
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13.160551 |