Label free identification of the different status of anemia disease using optimized double-slot cascaded microring resonator

• Main Authors: Bahadoran, Mahdi, Seyfari, Abbas Kalate, Sanati, Parisa, Chua, Lee Suan
• Format: Article
• Language: English
• Published: Nature Research 2022
• Subjects: Q Science (General)
• Online Access: http://eprints.utm.my/103974/1/ChuaLeeSuan2022_LabelFreeIdentificationoftheDifferentStatus.pdf; http://eprints.utm.my/103974/; http://dx.doi.org/10.1038/s41598-022-09504-2

An optical-based label-free biosensors including two indirectly coupled double-slot-waveguide-based microring resonator was designed and optimized for sensing purpose. Then, the optimized system was applied for the detection of hemoglobin concentration in anemia disease. The results were simulated based on the variational finite-difference time domain (varFDTD) method using the Lumerical software (Mode solutions) and the optimum geometrical parameters were determined to realize an optimum light transmission via the sensor. Nine different concentrations of hemoglobin in men and women were applied into the sensor and the status of anemia was identified based on the patients’ gender and different status of anemia disease, including the normal, mild, moderate, severe and life-threatening status. A sensitivity as high as 1024 nm/RIU with the minimum deflection limit of 4.88 × 10–6 RIU were measured for this biosensor, which introduces a high precision and micro-scale lab-on-a-chip micro device for health monitoring of the anemia.