Molecular dynamics simulations on structural differences of glucose-6-phosphate dehydrogenase deficiency variants among the Asian population

• Main Author: Richard Louis, Naveen Eugene Louis
• Format: Thesis
• Language: English
• Published: 2022
• Subjects: Q Science (General)
• Online Access: http://eprints.utm.my/id/eprint/102449/1/NaveenEugeneLouisMFS2022.pdf.pdf; http://eprints.utm.my/id/eprint/102449/; http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:148981

Glucose-6-phosphate dehydrogenase (G6PD) is responsible for red blood cell protection against free radicals. There are over 186 G6PD deficient variants which adversely affected the enzyme activity. In its active state, G6PD exists in dynamic equilibrium as dimer and tetramer, influenced by its ligan...