A hybrid of bees algorithm and regulatory on/off minimization for optimizing lactate production
Metabolic engineering has grown dramatically and is now widely used, particularly in the production of biomass utilising microorganisms. The metabolic network model has been extensively used in computational procedures developed to optimise metabolic production and suggest modifications in organisms...
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my.utm.1013842023-06-14T09:52:26Z http://eprints.utm.my/id/eprint/101384/ A hybrid of bees algorithm and regulatory on/off minimization for optimizing lactate production Yong, Mohd. Izzat Mohamad, Mohd. Saberi Choon, Yee Wen Chan, Weng Howe Adli, Hasyiya Karimah Wan Salihin Wong, Khairul Nizar Syazwan Yusoff, Nooraini Remli, Muhammad Akmal Q Science (General) QA75 Electronic computers. Computer science Metabolic engineering has grown dramatically and is now widely used, particularly in the production of biomass utilising microorganisms. The metabolic network model has been extensively used in computational procedures developed to optimise metabolic production and suggest modifications in organisms. The problem has been the unrealistic flux distribution suggestion demonstrated by previous work on a rational modelling framework employing Optknock and OptGene. To address the issue, a hybrid of the Bees Algorithm and Regulatory On/Off Minimization (BAROOM) is introduced. By using Eschericia coli (E. coli) as the model organism, BAROOM is able to determine the optimal set of gene that can be knocked out and improve lactate production. The results show that BAROOM performs better than other methods in increasing lactate production in model organism by identifying optimal set of genes to be knocked out. 2022 Conference or Workshop Item PeerReviewed Yong, Mohd. Izzat and Mohamad, Mohd. Saberi and Choon, Yee Wen and Chan, Weng Howe and Adli, Hasyiya Karimah and Wan Salihin Wong, Khairul Nizar Syazwan and Yusoff, Nooraini and Remli, Muhammad Akmal (2022) A hybrid of bees algorithm and regulatory on/off minimization for optimizing lactate production. In: 15th International Conference on Practical Applications of Computational Biology and Bioinformatics, PACBB 2021, 6 October 2021 - 8 October 2021, Salamanca, Spain. http://dx.doi.org/10.1007/978-3-030-86258-9_10 |
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Q Science (General) QA75 Electronic computers. Computer science Yong, Mohd. Izzat Mohamad, Mohd. Saberi Choon, Yee Wen Chan, Weng Howe Adli, Hasyiya Karimah Wan Salihin Wong, Khairul Nizar Syazwan Yusoff, Nooraini Remli, Muhammad Akmal A hybrid of bees algorithm and regulatory on/off minimization for optimizing lactate production |
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Metabolic engineering has grown dramatically and is now widely used, particularly in the production of biomass utilising microorganisms. The metabolic network model has been extensively used in computational procedures developed to optimise metabolic production and suggest modifications in organisms. The problem has been the unrealistic flux distribution suggestion demonstrated by previous work on a rational modelling framework employing Optknock and OptGene. To address the issue, a hybrid of the Bees Algorithm and Regulatory On/Off Minimization (BAROOM) is introduced. By using Eschericia coli (E. coli) as the model organism, BAROOM is able to determine the optimal set of gene that can be knocked out and improve lactate production. The results show that BAROOM performs better than other methods in increasing lactate production in model organism by identifying optimal set of genes to be knocked out. |
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Conference or Workshop Item |
author |
Yong, Mohd. Izzat Mohamad, Mohd. Saberi Choon, Yee Wen Chan, Weng Howe Adli, Hasyiya Karimah Wan Salihin Wong, Khairul Nizar Syazwan Yusoff, Nooraini Remli, Muhammad Akmal |
author_facet |
Yong, Mohd. Izzat Mohamad, Mohd. Saberi Choon, Yee Wen Chan, Weng Howe Adli, Hasyiya Karimah Wan Salihin Wong, Khairul Nizar Syazwan Yusoff, Nooraini Remli, Muhammad Akmal |
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Yong, Mohd. Izzat |
title |
A hybrid of bees algorithm and regulatory on/off minimization for optimizing lactate production |
title_short |
A hybrid of bees algorithm and regulatory on/off minimization for optimizing lactate production |
title_full |
A hybrid of bees algorithm and regulatory on/off minimization for optimizing lactate production |
title_fullStr |
A hybrid of bees algorithm and regulatory on/off minimization for optimizing lactate production |
title_full_unstemmed |
A hybrid of bees algorithm and regulatory on/off minimization for optimizing lactate production |
title_sort |
hybrid of bees algorithm and regulatory on/off minimization for optimizing lactate production |
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2022 |
url |
http://eprints.utm.my/id/eprint/101384/ http://dx.doi.org/10.1007/978-3-030-86258-9_10 |
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