Exploring the anticancer activities of novel bioactive compounds derived from endophytic fungi: mechanisms of action, current challenges and future perspectives
Cancer is the second leading cause of death all around the world. The natural compounds derived from the endophytic flora of fungi are possible solutions to cancer treatment because they are safe for health, cost-effective, biocompatible and have fewer toxicity issues. The active ingredients in endo...
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my.utm.1007952023-04-30T11:37:37Z http://eprints.utm.my/id/eprint/100795/ Exploring the anticancer activities of novel bioactive compounds derived from endophytic fungi: mechanisms of action, current challenges and future perspectives Kousar, Rubina Muhammad Naeem, Muhammad Naeem Jamaludin, Mohamad Ikhwan Arshad, Ammara Shamsuri, Aisyah Nazirah Ansari, Nelofar Akhtar, Samreen Abu Hazafa, Abu Hazafa Uddin, Jalal Khan, Ajmal Al-Harrasi, Ahmed TK Electrical engineering. Electronics Nuclear engineering Cancer is the second leading cause of death all around the world. The natural compounds derived from the endophytic flora of fungi are possible solutions to cancer treatment because they are safe for health, cost-effective, biocompatible and have fewer toxicity issues. The active ingredients in endophytic fungi that are responsible for anti-cancer activities are alkaloids, terpenoids, glycosides, saponin, peptides, steroids, phenols, quinones, and flavonoids. This review highlights the anti-cancer activities of entophytic fungus against human papillary thyroid carcinoma (IHH4), human pancreatic (PANC-1), ovarian (OVCAR-3), hepatic (HepG2), lung (A-549), human lymphoma (U937), human skin carcinoma (A431), breast (MCF-7), and Kaposi's sarcoma. The emerging evidence suggested that bioactive compounds isolated from endophytic fungi showed their anti-cancer activities by revealing the disturbance of the microtubule network caused by increased levels of Bax and Bcl-2 proteins that triggers cell cycle arrest at the G2-M phase, by inhibiting the DNA replication via binding with topoisomerase II, by regulating the activity of extracellular signal-regulated kinase and NF-kB, by evaluating the levels of p21, p27, and cyclins B/D1/E that led to cell death by apoptosis and cell cycle arrest. This review will assist readers in better comprehending bioactive chemicals and the beneficial interaction between the fungal endophytes and medicinal plants. PubMed 2022 Article PeerReviewed Kousar, Rubina and Muhammad Naeem, Muhammad Naeem and Jamaludin, Mohamad Ikhwan and Arshad, Ammara and Shamsuri, Aisyah Nazirah and Ansari, Nelofar and Akhtar, Samreen and Abu Hazafa, Abu Hazafa and Uddin, Jalal and Khan, Ajmal and Al-Harrasi, Ahmed (2022) Exploring the anticancer activities of novel bioactive compounds derived from endophytic fungi: mechanisms of action, current challenges and future perspectives. American Journal of Cancer Research, 12 (7). pp. 2897-2919. ISSN 2156-6976 https://pubmed.ncbi.nlm.nih.gov/35968347/ NA |
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TK Electrical engineering. Electronics Nuclear engineering Kousar, Rubina Muhammad Naeem, Muhammad Naeem Jamaludin, Mohamad Ikhwan Arshad, Ammara Shamsuri, Aisyah Nazirah Ansari, Nelofar Akhtar, Samreen Abu Hazafa, Abu Hazafa Uddin, Jalal Khan, Ajmal Al-Harrasi, Ahmed Exploring the anticancer activities of novel bioactive compounds derived from endophytic fungi: mechanisms of action, current challenges and future perspectives |
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Cancer is the second leading cause of death all around the world. The natural compounds derived from the endophytic flora of fungi are possible solutions to cancer treatment because they are safe for health, cost-effective, biocompatible and have fewer toxicity issues. The active ingredients in endophytic fungi that are responsible for anti-cancer activities are alkaloids, terpenoids, glycosides, saponin, peptides, steroids, phenols, quinones, and flavonoids. This review highlights the anti-cancer activities of entophytic fungus against human papillary thyroid carcinoma (IHH4), human pancreatic (PANC-1), ovarian (OVCAR-3), hepatic (HepG2), lung (A-549), human lymphoma (U937), human skin carcinoma (A431), breast (MCF-7), and Kaposi's sarcoma. The emerging evidence suggested that bioactive compounds isolated from endophytic fungi showed their anti-cancer activities by revealing the disturbance of the microtubule network caused by increased levels of Bax and Bcl-2 proteins that triggers cell cycle arrest at the G2-M phase, by inhibiting the DNA replication via binding with topoisomerase II, by regulating the activity of extracellular signal-regulated kinase and NF-kB, by evaluating the levels of p21, p27, and cyclins B/D1/E that led to cell death by apoptosis and cell cycle arrest. This review will assist readers in better comprehending bioactive chemicals and the beneficial interaction between the fungal endophytes and medicinal plants. |
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Article |
author |
Kousar, Rubina Muhammad Naeem, Muhammad Naeem Jamaludin, Mohamad Ikhwan Arshad, Ammara Shamsuri, Aisyah Nazirah Ansari, Nelofar Akhtar, Samreen Abu Hazafa, Abu Hazafa Uddin, Jalal Khan, Ajmal Al-Harrasi, Ahmed |
author_facet |
Kousar, Rubina Muhammad Naeem, Muhammad Naeem Jamaludin, Mohamad Ikhwan Arshad, Ammara Shamsuri, Aisyah Nazirah Ansari, Nelofar Akhtar, Samreen Abu Hazafa, Abu Hazafa Uddin, Jalal Khan, Ajmal Al-Harrasi, Ahmed |
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Kousar, Rubina |
title |
Exploring the anticancer activities of novel bioactive compounds derived from endophytic fungi: mechanisms of action, current challenges and future perspectives |
title_short |
Exploring the anticancer activities of novel bioactive compounds derived from endophytic fungi: mechanisms of action, current challenges and future perspectives |
title_full |
Exploring the anticancer activities of novel bioactive compounds derived from endophytic fungi: mechanisms of action, current challenges and future perspectives |
title_fullStr |
Exploring the anticancer activities of novel bioactive compounds derived from endophytic fungi: mechanisms of action, current challenges and future perspectives |
title_full_unstemmed |
Exploring the anticancer activities of novel bioactive compounds derived from endophytic fungi: mechanisms of action, current challenges and future perspectives |
title_sort |
exploring the anticancer activities of novel bioactive compounds derived from endophytic fungi: mechanisms of action, current challenges and future perspectives |
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PubMed |
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2022 |
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http://eprints.utm.my/id/eprint/100795/ https://pubmed.ncbi.nlm.nih.gov/35968347/ |
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1765296703213142016 |
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13.18916 |