Pseudomonas aeruginosa behaviour in polymicrobial communities: The competitive and cooperative interactions conducting to the exacerbation of infections
Pseudomonas aeruginosa is mostly associated with persistent infections and antibiotic resistance as a result of several factors, biofilms one of them. Microorganisms within the polymicrobial biofilm (PMB) reveal various transcriptional profiles and affect each other which might influence their pat...
Saved in:
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2023
|
Subjects: | |
Online Access: | http://eprints.uthm.edu.my/9077/1/J15781_860fdec6791c69e4bf38cf028ce77bfe.pdf http://eprints.uthm.edu.my/9077/ https://doi.org/10.1016/j.micres.2022.127298 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
my.uthm.eprints.9077 |
---|---|
record_format |
eprints |
spelling |
my.uthm.eprints.90772023-06-25T07:10:44Z http://eprints.uthm.edu.my/9077/ Pseudomonas aeruginosa behaviour in polymicrobial communities: The competitive and cooperative interactions conducting to the exacerbation of infections Al-Wrafy, Fairoz Ali Alariqi, Reem Ali Noman, Efaq Al-Gheethi, Adel Ali Mutahar, Mahdi T Technology (General) Pseudomonas aeruginosa is mostly associated with persistent infections and antibiotic resistance as a result of several factors, biofilms one of them. Microorganisms within the polymicrobial biofilm (PMB) reveal various transcriptional profiles and affect each other which might influence their pathogenicity and antibiotic tolerance and subsequent worsening of the biofilm infection. P. aeruginosa within PMB exhibits various behaviours toward other microorganisms, which may enhance or repress the virulence of these microbes. Microbial neighbours, in turn, may affect P. aeruginosa’s virulence either positively or negatively. Such interactions among microorganisms lead to emerging persistent and antibiotic-resistant infections. This review highlights the relationship between P. aeruginosa and its microbial neighbours within the PMB in an attempt to better understand the mechanisms of polymicrobial interaction and the correlation between increased exacerbations of infection and the P. aeruginosa-microbe interaction. Researching in the literature that was carried out in vitro either in cocultures or in the models to simulate the environment at the site of infection suggested that the interplay between P. aeruginosa and other microorganisms is one main reason for the worsening of the infection and which in turn requires a treatment approach different from that followed with P. aeruginosa mono-infection. Elsevier 2023 Article PeerReviewed text en http://eprints.uthm.edu.my/9077/1/J15781_860fdec6791c69e4bf38cf028ce77bfe.pdf Al-Wrafy, Fairoz Ali and Alariqi, Reem and Ali Noman, Efaq and Al-Gheethi, Adel Ali and Mutahar, Mahdi (2023) Pseudomonas aeruginosa behaviour in polymicrobial communities: The competitive and cooperative interactions conducting to the exacerbation of infections. Microbiological Research, 268. pp. 1-11. https://doi.org/10.1016/j.micres.2022.127298 |
institution |
Universiti Tun Hussein Onn Malaysia |
building |
UTHM Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
Universiti Tun Hussein Onn Malaysia |
content_source |
UTHM Institutional Repository |
url_provider |
http://eprints.uthm.edu.my/ |
language |
English |
topic |
T Technology (General) |
spellingShingle |
T Technology (General) Al-Wrafy, Fairoz Ali Alariqi, Reem Ali Noman, Efaq Al-Gheethi, Adel Ali Mutahar, Mahdi Pseudomonas aeruginosa behaviour in polymicrobial communities: The competitive and cooperative interactions conducting to the exacerbation of infections |
description |
Pseudomonas aeruginosa is mostly associated with persistent infections and antibiotic resistance as a result of
several factors, biofilms one of them. Microorganisms within the polymicrobial biofilm (PMB) reveal various
transcriptional profiles and affect each other which might influence their pathogenicity and antibiotic tolerance
and subsequent worsening of the biofilm infection. P. aeruginosa within PMB exhibits various behaviours toward
other microorganisms, which may enhance or repress the virulence of these microbes. Microbial neighbours, in
turn, may affect P. aeruginosa’s virulence either positively or negatively. Such interactions among microorganisms lead to emerging persistent and antibiotic-resistant infections. This review highlights the relationship between P. aeruginosa and its microbial neighbours within the PMB in an attempt to better understand the mechanisms of polymicrobial interaction and the correlation between increased exacerbations of infection and the P. aeruginosa-microbe interaction. Researching in the literature that was carried out in vitro either in cocultures or in the models to simulate the environment at the site of infection suggested that the interplay between P. aeruginosa and other microorganisms is one main reason for the worsening of the infection and which in turn requires a treatment approach different from that followed with P. aeruginosa mono-infection. |
format |
Article |
author |
Al-Wrafy, Fairoz Ali Alariqi, Reem Ali Noman, Efaq Al-Gheethi, Adel Ali Mutahar, Mahdi |
author_facet |
Al-Wrafy, Fairoz Ali Alariqi, Reem Ali Noman, Efaq Al-Gheethi, Adel Ali Mutahar, Mahdi |
author_sort |
Al-Wrafy, Fairoz Ali |
title |
Pseudomonas aeruginosa behaviour in polymicrobial communities: The competitive and cooperative interactions conducting to the exacerbation of infections |
title_short |
Pseudomonas aeruginosa behaviour in polymicrobial communities: The competitive and cooperative interactions conducting to the exacerbation of infections |
title_full |
Pseudomonas aeruginosa behaviour in polymicrobial communities: The competitive and cooperative interactions conducting to the exacerbation of infections |
title_fullStr |
Pseudomonas aeruginosa behaviour in polymicrobial communities: The competitive and cooperative interactions conducting to the exacerbation of infections |
title_full_unstemmed |
Pseudomonas aeruginosa behaviour in polymicrobial communities: The competitive and cooperative interactions conducting to the exacerbation of infections |
title_sort |
pseudomonas aeruginosa behaviour in polymicrobial communities: the competitive and cooperative interactions conducting to the exacerbation of infections |
publisher |
Elsevier |
publishDate |
2023 |
url |
http://eprints.uthm.edu.my/9077/1/J15781_860fdec6791c69e4bf38cf028ce77bfe.pdf http://eprints.uthm.edu.my/9077/ https://doi.org/10.1016/j.micres.2022.127298 |
_version_ |
1769845136235167744 |
score |
13.19449 |