Robustness evaluations of pathway activity inference methods on gene expression data

• Main Authors: Tay Xin Hui, Tay Xin Hui, Kasim, Shahreen, Abdul Aziz, Izzatdin, Md Fudzee, Mohd Farhan, Haron, Nazleeni Samiha, Tole Sutikno, Tole Sutikno, Hassan, Rohayanti, Mahdin, Hairulnizam, Seah Choon Sen, Seah Choon Sen
• Format: Article
• Language: English
• Published: BMC 2024
• Subjects: T Technology (General)
• Online Access: http://eprints.uthm.edu.my/10952/1/J17448_cf6902c993cf26570c682ba1f102f077.pdf; http://eprints.uthm.edu.my/10952/; https://doi.org/10.1186/s12859-024-05632-w

Background: With the exponential growth of high-throughput technologies, multiple pathway analysis methods have been proposed to estimate pathway activities from gene expression profles. These pathway activity inference methods can be divided into two main categories: non-Topology-Based (non-TB) and...