Psychrophilic enzymes: structural adaptation, pharmaceutical and industrial applications
Psychrophiles are cold-living microorganisms synthesizing enzymes that are permanently active at almost near-zero temperatures. Psychrozymes are supposed to be structurally more flexible than their homologous proteins. This structural flexibility enables these proteins to undergo conformational ch...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer
2020
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| Subjects: | |
| Online Access: | http://eprints.uthm.edu.my/1081/1/J11981_3009d433f18f8d8e028012afd91a81c2.pdf http://eprints.uthm.edu.my/1081/ https://doi.org/10.1007/s00253-020-11074-0 |
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| Summary: | Psychrophiles are cold-living microorganisms synthesizing enzymes that are permanently active at almost near-zero temperatures.
Psychrozymes are supposed to be structurally more flexible than their homologous proteins. This structural flexibility
enables these proteins to undergo conformational changes during catalysis and improve catalytic efficiency at low temperatures.
The outstanding characteristics of the psychrophilic enzymes have attracted the attention of the scientific community to utilize
them in a wide variety of industrial and pharmaceutical applications. In this review, we first highlight the current knowledge of
the cold-adaptation mechanisms of the psychrophiles. In the sequel, we describe the potential applications of the enzymes in
different biotechnological processes specifically, in the production of industrial and pharmaceutical products. |
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