Immobilization of blood coagulant factor VII on polycaprolactone membrane through polydopamine grafting

• Main Authors: Rathosivan Gopal, Rathosivan Gopal, Md Shakhih, Muhammad Faiz, Mariaulpa Sahalan, Mariaulpa Sahalan, Te Chuan Lee, Te Chuan Lee, Hendra Hermawan, Hendra Hermawan, Sivakumar Sivalingam, Sivakumar Sivalingam, Kadiman, Suhaini, Saidin, Syafiqah
• Format: Article
• Language: English
• Published: Elsevier 2023
• Subjects: TP248.13-248.65 Biotechnology
• Online Access: http://eprints.uthm.edu.my/10094/1/J16187_a1d83041e2470ffe3771a93396a5cc32.pdf; http://eprints.uthm.edu.my/10094/; https://doi.org/10.1016/j.colsurfb.2023.113390

Postoperative bleeding following cardiac surgeries is still an issue that deranges the medical resources and cost. The oral and injection administrations of blood coagulation protein, Factor VII (FVII), is effective to stop the bleeding. However, its short half-life has limited the effectiveness of...