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Understanding Platelet Thrombogenicity Cascade Of The Biodegradable Chitosan Derivatives In Von Willebrand Disease In Vitro

Chitosan has become one of the most promising local hemostatic agents because it is of particular interest as it functions independently on platelets and normal clotting mechanisms. The present study was designed with the aim to test the ability of the mechanisms of blood platelets towards the ac...

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Main Author: Periayah, Mercy Halleluyah
Format: Thesis
Language:English
Published: 2015
Subjects:
R735-854 Medical education. Medical schools. Research
Online Access:http://eprints.usm.my/61120/1/8%20bit%20cmos%20hybrid%20cut.pdf
http://eprints.usm.my/61120/
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spelling my.usm.eprints.61120 http://eprints.usm.my/61120/ Understanding Platelet Thrombogenicity Cascade Of The Biodegradable Chitosan Derivatives In Von Willebrand Disease In Vitro Periayah, Mercy Halleluyah R735-854 Medical education. Medical schools. Research Chitosan has become one of the most promising local hemostatic agents because it is of particular interest as it functions independently on platelets and normal clotting mechanisms. The present study was designed with the aim to test the ability of the mechanisms of blood platelets towards the action of biodegradable chitosan in normal donors and von Willebrand disease (vWD) patients in vitro. This work determined the underlying mechanism of chitosan-induced platelet thrombogenicity and comprises experimental tests such as degradation ability; platelet: adhesion, activation: aggregation; coagulation analysis and hemostatic mediators: von Willebrand Factor (vWF), Factor 8 (FVIII), Thromboxane A2 (TXA2), P2Y12, glycoprotein IIbIIIa (GpIIbIIIa), Transforming Growth Factor- Beta 1 (TGF-β1) and Platelet Derived Growth Factor-AB (PDGF-AB). Comparative studies have been conducted to measure the hemostatic capacity of biodegradable 7% N,OCarboxymethylchitosan (NO-CMC) (with 0.45 mL collagen), 8% NO-CMC, Oligochitosan (O-C) and O-C 53. 2015-11 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/61120/1/8%20bit%20cmos%20hybrid%20cut.pdf Periayah, Mercy Halleluyah (2015) Understanding Platelet Thrombogenicity Cascade Of The Biodegradable Chitosan Derivatives In Von Willebrand Disease In Vitro. PhD thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic R735-854 Medical education. Medical schools. Research
spellingShingle R735-854 Medical education. Medical schools. Research
Periayah, Mercy Halleluyah
Understanding Platelet Thrombogenicity Cascade Of The Biodegradable Chitosan Derivatives In Von Willebrand Disease In Vitro
description Chitosan has become one of the most promising local hemostatic agents because it is of particular interest as it functions independently on platelets and normal clotting mechanisms. The present study was designed with the aim to test the ability of the mechanisms of blood platelets towards the action of biodegradable chitosan in normal donors and von Willebrand disease (vWD) patients in vitro. This work determined the underlying mechanism of chitosan-induced platelet thrombogenicity and comprises experimental tests such as degradation ability; platelet: adhesion, activation: aggregation; coagulation analysis and hemostatic mediators: von Willebrand Factor (vWF), Factor 8 (FVIII), Thromboxane A2 (TXA2), P2Y12, glycoprotein IIbIIIa (GpIIbIIIa), Transforming Growth Factor- Beta 1 (TGF-β1) and Platelet Derived Growth Factor-AB (PDGF-AB). Comparative studies have been conducted to measure the hemostatic capacity of biodegradable 7% N,OCarboxymethylchitosan (NO-CMC) (with 0.45 mL collagen), 8% NO-CMC, Oligochitosan (O-C) and O-C 53.
format Thesis
author Periayah, Mercy Halleluyah
author_facet Periayah, Mercy Halleluyah
author_sort Periayah, Mercy Halleluyah
title Understanding Platelet Thrombogenicity Cascade Of The Biodegradable Chitosan Derivatives In Von Willebrand Disease In Vitro
title_short Understanding Platelet Thrombogenicity Cascade Of The Biodegradable Chitosan Derivatives In Von Willebrand Disease In Vitro
title_full Understanding Platelet Thrombogenicity Cascade Of The Biodegradable Chitosan Derivatives In Von Willebrand Disease In Vitro
title_fullStr Understanding Platelet Thrombogenicity Cascade Of The Biodegradable Chitosan Derivatives In Von Willebrand Disease In Vitro
title_full_unstemmed Understanding Platelet Thrombogenicity Cascade Of The Biodegradable Chitosan Derivatives In Von Willebrand Disease In Vitro
title_sort understanding platelet thrombogenicity cascade of the biodegradable chitosan derivatives in von willebrand disease in vitro
publishDate 2015
url http://eprints.usm.my/61120/1/8%20bit%20cmos%20hybrid%20cut.pdf
http://eprints.usm.my/61120/
_version_ 1811683103971737600
score 13.2014675

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