Anti-Apoptotic Proteins Mcl-1 And Bcl-Xl Are Crucial For Nasopharyngeal Carcinoma Cell Survival
Malaysia has one of the highest national incidences of Nasopharyngeal carcinoma (NPC) in South-East Asia. Treating patients with metastatic NPC is often a challenge as patients develop resistance to systemic anti-cancer therapies such as chemotherapy and retreating local recurrence with radiother...
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| Main Author: | |
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| Format: | Thesis |
| Language: | English |
| Published: |
2022
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| Subjects: | |
| Online Access: | http://eprints.usm.my/60127/1/24%20Pages%20from%20SITI%20FAIRUS%20BINTI%20ABDUL%20RAHMAN.pdf http://eprints.usm.my/60127/ |
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| Summary: | Malaysia has one of the highest national incidences of Nasopharyngeal
carcinoma (NPC) in South-East Asia. Treating patients with metastatic NPC is often a
challenge as patients develop resistance to systemic anti-cancer therapies such as
chemotherapy and retreating local recurrence with radiotherapy have many limitations.
Hence, improved treatment strategies are needed for better patient outcome. Upregulation
of the anti-apoptotic protein BCL-2 is one of the strategies that cancer cells
adopt to evade cell death. Hence, these proteins have become attractive therapeutic
targets. Given that different cell population rely on different anti-apoptotic proteins for
survival, it is crucial to determine which proteins are important for NPC cell survival.
Previous study reported that co-inhibition of BCL-2 and BCL-XL did not induce cell
killing in NPC cells, which indicate that either MCL-1 or BFL-1 may play an important
role in the survival the NPC cells. Given that the roles of MCL-1 and BFL-1 for NPC
cell survival are under-explored, this study will primarily focus on delineating the
functional roles of these two molecules for cell survival using gene editing and
pharmacological approaches. |
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