The mechanism of osseointegration on hydroxypatite (ha)-induced osteoblast stimulated with cytokines
Advancement in oral implant research have led to remarkable transformation in osseointegration technology. ' However, current implants often encounter complications in its compatibility due to own immune rejection. Numerous surface coatings and growth factors have been widely explored to ove...
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my.usm.eprints.59943 http://eprints.usm.my/59943/ The mechanism of osseointegration on hydroxypatite (ha)-induced osteoblast stimulated with cytokines Abdullah, Nurul Asma R Medicine RC31-1245 Internal medicine Advancement in oral implant research have led to remarkable transformation in osseointegration technology. ' However, current implants often encounter complications in its compatibility due to own immune rejection. Numerous surface coatings and growth factors have been widely explored to overcome these complications. Hydroxyapatite (HA) displays properties more likely to the mineral elements of human bones and hard tissues and is commonly used as a filler to replace bone or as a coating material. lnterleukins such as IL-6 and IL-17 which acts as key control in the immune response has been identified to have potential role in I bone metabolism. Understanding of bone metabolism implies the involvement of osteoprotegerin (OPG) and receptor activator of RANK ligand (RANKL) that balances the whole metabolism. RANKL stimulates osteoclastogenesis while the OPG regulates osteogenesis. This study aimed to understand the role of IL-6 and IL-17A in modulating OPG/RANKL system on HA-induced murine osteoblast cell line (MCT3T-E1). Treatments of IL-6 or in combination with IL-17A resulted in an increased expression of OPG and ALP, in contrast to RANKL expression; thus improved the OPG/RANKL ratio. In addition, bone mineralization process is indicated through up-regulation of ALP activity. Treatment of HA-induced osteoblast with IL-6 ± IL- 17A modulates the OPG/RANKL system, thus enhanced osteogenesis and bone remodeling process. Pusat Pengajian Kesihatan 2015 Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/59943/1/DR%20AZIAH%20ISMAIL%20-%20e.pdf Abdullah, Nurul Asma (2015) The mechanism of osseointegration on hydroxypatite (ha)-induced osteoblast stimulated with cytokines. Project Report. Pusat Pengajian Kesihatan. (Submitted) |
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R Medicine RC31-1245 Internal medicine Abdullah, Nurul Asma The mechanism of osseointegration on hydroxypatite (ha)-induced osteoblast stimulated with cytokines |
description |
Advancement in oral implant research have led to remarkable transformation in osseointegration technology.
'
However, current implants often encounter complications in its compatibility due to own immune rejection.
Numerous surface coatings and growth factors have been widely explored to overcome these complications.
Hydroxyapatite (HA) displays properties more likely to the mineral elements of human bones and hard
tissues and is commonly used as a filler to replace bone or as a coating material. lnterleukins such as IL-6
and IL-17 which acts as key control in the immune response has been identified to have potential role in
I bone metabolism. Understanding of bone metabolism implies the involvement of osteoprotegerin (OPG) and
receptor activator of RANK ligand (RANKL) that balances the whole metabolism. RANKL stimulates
osteoclastogenesis while the OPG regulates osteogenesis. This study aimed to understand the role of IL-6
and IL-17A in modulating OPG/RANKL system on HA-induced murine osteoblast cell line (MCT3T-E1).
Treatments of IL-6 or in combination with IL-17A resulted in an increased expression of OPG and ALP, in
contrast to RANKL expression; thus improved the OPG/RANKL ratio. In addition, bone mineralization
process is indicated through up-regulation of ALP activity. Treatment of HA-induced osteoblast with IL-6 ± IL-
17A modulates the OPG/RANKL system, thus enhanced osteogenesis and bone remodeling process. |
format |
Monograph |
author |
Abdullah, Nurul Asma |
author_facet |
Abdullah, Nurul Asma |
author_sort |
Abdullah, Nurul Asma |
title |
The mechanism of osseointegration on
hydroxypatite (ha)-induced osteoblast
stimulated with cytokines |
title_short |
The mechanism of osseointegration on
hydroxypatite (ha)-induced osteoblast
stimulated with cytokines |
title_full |
The mechanism of osseointegration on
hydroxypatite (ha)-induced osteoblast
stimulated with cytokines |
title_fullStr |
The mechanism of osseointegration on
hydroxypatite (ha)-induced osteoblast
stimulated with cytokines |
title_full_unstemmed |
The mechanism of osseointegration on
hydroxypatite (ha)-induced osteoblast
stimulated with cytokines |
title_sort |
mechanism of osseointegration on
hydroxypatite (ha)-induced osteoblast
stimulated with cytokines |
publisher |
Pusat Pengajian Kesihatan |
publishDate |
2015 |
url |
http://eprints.usm.my/59943/1/DR%20AZIAH%20ISMAIL%20-%20e.pdf http://eprints.usm.my/59943/ |
_version_ |
1795011135110381568 |
score |
13.160551 |