Identification Of Antimalarial Compounds And Their Mode Of Actions

Malaria is one of the most significant infectious diseases in the tropics, claiming around half-million lives annually, mainly due to Plasmodium falciparum (P. falciparum) infections. To date, P. falciparum has developed full or partial resistance towards all three classes of antimalarials, inclu...

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Main Author: Mahmud, Fauze
Format: Thesis
Language:English
Published: 2022
Subjects:
Online Access:http://eprints.usm.my/59690/1/24%20Pages%20from%20FAUZE%20BIN%20MAHMUD%20-%20TESIS.pdf
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spelling my.usm.eprints.59690 http://eprints.usm.my/59690/ Identification Of Antimalarial Compounds And Their Mode Of Actions Mahmud, Fauze R5-920 Medicine (General) Malaria is one of the most significant infectious diseases in the tropics, claiming around half-million lives annually, mainly due to Plasmodium falciparum (P. falciparum) infections. To date, P. falciparum has developed full or partial resistance towards all three classes of antimalarials, including against the artemisinin. Hence, it may jeopardize the efficacy of the current antimalarial treatment regimen, the Artemisinin Combination Therapy (ACT), in the near future. Therefore, there is an utmost need to identify a new antimalarial compound with a novel mode of action (MoA). This study mainly focused on identifying antimalarial compounds from soil microorganisms isolated from Malaysia and Japan. The crude extracts of these strains showed potent antimalarial activity in a preliminary assay against Pf 3D7 (wild type). The crude extracts of Malaysian strains also inhibited the activity of human GSK-3β (75 % similar to P. Falciparum GSK-3 (Pf GSK-3)). 2022-10 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/59690/1/24%20Pages%20from%20FAUZE%20BIN%20MAHMUD%20-%20TESIS.pdf Mahmud, Fauze (2022) Identification Of Antimalarial Compounds And Their Mode Of Actions. PhD thesis, Perpustakaan Hamzah Sendut.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic R5-920 Medicine (General)
spellingShingle R5-920 Medicine (General)
Mahmud, Fauze
Identification Of Antimalarial Compounds And Their Mode Of Actions
description Malaria is one of the most significant infectious diseases in the tropics, claiming around half-million lives annually, mainly due to Plasmodium falciparum (P. falciparum) infections. To date, P. falciparum has developed full or partial resistance towards all three classes of antimalarials, including against the artemisinin. Hence, it may jeopardize the efficacy of the current antimalarial treatment regimen, the Artemisinin Combination Therapy (ACT), in the near future. Therefore, there is an utmost need to identify a new antimalarial compound with a novel mode of action (MoA). This study mainly focused on identifying antimalarial compounds from soil microorganisms isolated from Malaysia and Japan. The crude extracts of these strains showed potent antimalarial activity in a preliminary assay against Pf 3D7 (wild type). The crude extracts of Malaysian strains also inhibited the activity of human GSK-3β (75 % similar to P. Falciparum GSK-3 (Pf GSK-3)).
format Thesis
author Mahmud, Fauze
author_facet Mahmud, Fauze
author_sort Mahmud, Fauze
title Identification Of Antimalarial Compounds And Their Mode Of Actions
title_short Identification Of Antimalarial Compounds And Their Mode Of Actions
title_full Identification Of Antimalarial Compounds And Their Mode Of Actions
title_fullStr Identification Of Antimalarial Compounds And Their Mode Of Actions
title_full_unstemmed Identification Of Antimalarial Compounds And Their Mode Of Actions
title_sort identification of antimalarial compounds and their mode of actions
publishDate 2022
url http://eprints.usm.my/59690/1/24%20Pages%20from%20FAUZE%20BIN%20MAHMUD%20-%20TESIS.pdf
http://eprints.usm.my/59690/
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score 13.154949