Qualitative and Quantitative Analyses Of SMN 2 Gene Expression Upon Exposure with Histone De-acetylase Inhibitors and Polyphenols

• Main Author: Sasongko, Teguh Haryo
• Format: Monograph
• Language: English
• Published: Pusat Pengajian Sains Kesihatan, Universiti Sains Malaysia 2016
• Subjects: RD Surgery
• Online Access: http://eprints.usm.my/58132/1/DR%20TEGUH%20HARYO%20SASONGKO-Eprints.pdf; http://eprints.usm.my/58132/

Autosomal recessive SMA (Spinal Muscular Atrophy) is the second most common inherited disease, leading to early infancy death. The SMN1 mutations are leading cause of SMA. However, increasing expression of SMN2 has been exploited as therapeutic target for SMA. Several Histone Deacetylase Inhibito...