Analyses of DNA variants in Malays with Hereditary Nonpolyposis Colorectal Cancer (HNPCC)

• Main Author: Zakaria, Andee Dzulkarmaen
• Format: Monograph
• Language: English
• Published: Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia 2017
• Subjects: RB151-214 Theories of disease. Etiology. Pathogenesis; RC254-282 Neoplasms. Tumors. Oncology (including Cancer)
• Online Access: http://eprints.usm.my/57531/1/PROF%20MADYA%20DR%20ANDEE%20DZULKARMAEN%20ZAKARIA-Eprints.pdf; http://eprints.usm.my/57531/

Hereditary Nonpolyposis Colorectal Cancer (HNPCC) is caused by germline mutations in any of the Mismatch Repair (MMR) genes; MLH1, MSH2, MSH6 and PMS2 including EPCAM gene which is located upstream the MSH2 gene. This study aimed to investigate the underlying genetic variants in Malay HNPCC and of...