Effects of garcjnia mangostana linn. on wound healing in experimental wound models in rats: a preliminary study

• Main Author: Latib, Marzida Abd
• Format: Thesis
• Language: English
• Published: 2010
• Subjects: R Medicine (General)
• Online Access: http://eprints.usm.my/56223/1/DR%20MARZIDA%20ABD%20LATIB%20-%20e.pdf; http://eprints.usm.my/56223/

Wound healing is a very complex interplay between the overlapping phases, involving many cell types, mediators and growth factors. The an1ount of knowledge and understanding concerning the wound healing process and dressing practices has expanded and changed overtime. Its management is often costly. Therefore researchers are exploring alternative solution from natural sources that are useful in wound healing. Garcinia mangostana Linn. or mangosteen has never been scientifically studied for its wound healing potential. However there are numerous in vivo and in vitro studies that pointed to the medicinal properties of Garcinia mangostana L. Therefore this study aims to explore and relate the medicinal properties to wound healing in an animal wound model. The main objective of this study is to evaluate the effect of Garcinia mangostana L. on specific wound healing properties in rats namely wound contraction, period of epithelization and breaking strength. A semi quantitative histological examination was also performed. The wound contraction and epithelization were studied in an excision wound model which comprise of 10 rats in treatment group and 10 rats which were not treated acted as control. The wound breaking strength was studied in the incision wound model comprised of 6 rats in each group. This study demonstrated a significant increase in wound contraction at post operative day one and post operative day five in wounds treated with Garcinia mangostana L. extract with p value of< 0.001 and 0.005 respectively. It was also found that the wound breaking strength was significantly higher in the treatment group with p value of 0.04. Unfortunately semiquantitative histological analysis did not show any significant difference in inflammation, angiogenesis and fibroblast proliferation. In conclusion, Garcinia mangostana L. showed evidence of wound healing promotion. However the exact mechanism is still vague requiring further in vitro and in vivo studies before a clinical study could be performed.