Effect Of Leaching Agents On Polyurethane Composite Scaffolds Containing Bioactive Glass

Eight samples of porous polyurethane composite scaffolds containing 45S5 bioactive glass were fabricated by salt-particle leaching method. Each sample contains 80% polyurethane and 20% 45S5 bioactive glass. Two different leaching agents, namely NaCl and NaHCO3 were used to create the porous structur...

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Main Author: Lee, Angie
Format: Monograph
Language:English
Published: Universiti Sains Malaysia 2017
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Online Access:http://eprints.usm.my/52470/1/Effect%20Of%20Leaching%20Agents%20On%20Polyurethane%20Composite%20Scaffolds%20Containing%20Bioactive%20Glass_Lee%20Angie_B1_2017.pdf
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spelling my.usm.eprints.52470 http://eprints.usm.my/52470/ Effect Of Leaching Agents On Polyurethane Composite Scaffolds Containing Bioactive Glass Lee, Angie T Technology TA401-492 Materials of engineering and construction. Mechanics of materials Eight samples of porous polyurethane composite scaffolds containing 45S5 bioactive glass were fabricated by salt-particle leaching method. Each sample contains 80% polyurethane and 20% 45S5 bioactive glass. Two different leaching agents, namely NaCl and NaHCO3 were used to create the porous structure of scaffolds. The ratio between NaCl and NaHCO3 were varied, with NaCl:NaHCO3 percentage being 100:0, 95:5, 90:10, 85:15, 80:20, 75:25, 70:30 and 0:100. The porous scaffolds were characterized based on its pore morphology as well as its thermal and mechanical properties. Bonding properties of scaffold samples were studied using Fourier Transform Infrared Spectroscopy (FTIR), whereas its pore morphology were studied using Scanning Electron Microscopy (SEM). Porous scaffolds fabricated exhibits pores of which their sizes range from tens of microns to hundreds, which are suitable for bone tissue engineering. Thermal behaviour of samples were investigated using Thermogravimetric Analysis (TGA). Result shows that the percentage of residues remained in the scaffold (at 700°C) increases with increasing amount of NaHCO3. Mechanical properties of the produced scaffolds were studied by though compression test. Compressive modulus of the fabricated scaffolds ranges from 0.11 to 2.15 MPa. Besides that, the total porosity existing in the scaffold was studied as well. A minimum porosity of 70% porosity is usually required for biomedical applications, whereby in this study, majority of the samples fabricated has sufficient porosity to be used for bone tissue engineering. Universiti Sains Malaysia 2017-06-01 Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/52470/1/Effect%20Of%20Leaching%20Agents%20On%20Polyurethane%20Composite%20Scaffolds%20Containing%20Bioactive%20Glass_Lee%20Angie_B1_2017.pdf Lee, Angie (2017) Effect Of Leaching Agents On Polyurethane Composite Scaffolds Containing Bioactive Glass. Project Report. Universiti Sains Malaysia, Pusat Pengajian Kejuruteraan Bahan Sumber Mineral. (Submitted)
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic T Technology
TA401-492 Materials of engineering and construction. Mechanics of materials
spellingShingle T Technology
TA401-492 Materials of engineering and construction. Mechanics of materials
Lee, Angie
Effect Of Leaching Agents On Polyurethane Composite Scaffolds Containing Bioactive Glass
description Eight samples of porous polyurethane composite scaffolds containing 45S5 bioactive glass were fabricated by salt-particle leaching method. Each sample contains 80% polyurethane and 20% 45S5 bioactive glass. Two different leaching agents, namely NaCl and NaHCO3 were used to create the porous structure of scaffolds. The ratio between NaCl and NaHCO3 were varied, with NaCl:NaHCO3 percentage being 100:0, 95:5, 90:10, 85:15, 80:20, 75:25, 70:30 and 0:100. The porous scaffolds were characterized based on its pore morphology as well as its thermal and mechanical properties. Bonding properties of scaffold samples were studied using Fourier Transform Infrared Spectroscopy (FTIR), whereas its pore morphology were studied using Scanning Electron Microscopy (SEM). Porous scaffolds fabricated exhibits pores of which their sizes range from tens of microns to hundreds, which are suitable for bone tissue engineering. Thermal behaviour of samples were investigated using Thermogravimetric Analysis (TGA). Result shows that the percentage of residues remained in the scaffold (at 700°C) increases with increasing amount of NaHCO3. Mechanical properties of the produced scaffolds were studied by though compression test. Compressive modulus of the fabricated scaffolds ranges from 0.11 to 2.15 MPa. Besides that, the total porosity existing in the scaffold was studied as well. A minimum porosity of 70% porosity is usually required for biomedical applications, whereby in this study, majority of the samples fabricated has sufficient porosity to be used for bone tissue engineering.
format Monograph
author Lee, Angie
author_facet Lee, Angie
author_sort Lee, Angie
title Effect Of Leaching Agents On Polyurethane Composite Scaffolds Containing Bioactive Glass
title_short Effect Of Leaching Agents On Polyurethane Composite Scaffolds Containing Bioactive Glass
title_full Effect Of Leaching Agents On Polyurethane Composite Scaffolds Containing Bioactive Glass
title_fullStr Effect Of Leaching Agents On Polyurethane Composite Scaffolds Containing Bioactive Glass
title_full_unstemmed Effect Of Leaching Agents On Polyurethane Composite Scaffolds Containing Bioactive Glass
title_sort effect of leaching agents on polyurethane composite scaffolds containing bioactive glass
publisher Universiti Sains Malaysia
publishDate 2017
url http://eprints.usm.my/52470/1/Effect%20Of%20Leaching%20Agents%20On%20Polyurethane%20Composite%20Scaffolds%20Containing%20Bioactive%20Glass_Lee%20Angie_B1_2017.pdf
http://eprints.usm.my/52470/
_version_ 1732946313661644800
score 13.211869