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The Development Of Rosmarinic Acid Derivatives To Target Il17a In Glioblastoma Multiforme Via Angiogenic Pathways

In this study, glioblastoma inhibition was acheived via the disruption of IL17A, which blocks angiogenesis using new derivatives of rosmarinic acid (RA). Anti-GBM activity of the compounds were determined through cell migration and cell proliferation assays with U87 MG, DBTRG MG, and EA.hy 926 cells...

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Main Author: Khan, Md Shamsuddin Sultan
Format: Thesis
Language:English
Published: 2017
Subjects:
RS1-441 Pharmacy and materia medica
Online Access:http://eprints.usm.my/47701/1/THE%20DEVELOPMENT%20OF%20ROSMARINIC%20ACID.pdf%20cut.pdf
http://eprints.usm.my/47701/
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spelling my.usm.eprints.47701 http://eprints.usm.my/47701/ The Development Of Rosmarinic Acid Derivatives To Target Il17a In Glioblastoma Multiforme Via Angiogenic Pathways Khan, Md Shamsuddin Sultan RS1-441 Pharmacy and materia medica In this study, glioblastoma inhibition was acheived via the disruption of IL17A, which blocks angiogenesis using new derivatives of rosmarinic acid (RA). Anti-GBM activity of the compounds were determined through cell migration and cell proliferation assays with U87 MG, DBTRG MG, and EA.hy 926 cells. Antiangiogenic activity was investigated with tube formation, CAM, and aortic explant assays. The compounds’ activity in IL17A and VEGF expression was determined using ELISA and their apoptotic activity was assessed by the Caspase assay. The cancer pathway was determined using the reporter gene assay. 2017-09 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/47701/1/THE%20DEVELOPMENT%20OF%20ROSMARINIC%20ACID.pdf%20cut.pdf Khan, Md Shamsuddin Sultan (2017) The Development Of Rosmarinic Acid Derivatives To Target Il17a In Glioblastoma Multiforme Via Angiogenic Pathways. PhD thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic RS1-441 Pharmacy and materia medica
spellingShingle RS1-441 Pharmacy and materia medica
Khan, Md Shamsuddin Sultan
The Development Of Rosmarinic Acid Derivatives To Target Il17a In Glioblastoma Multiforme Via Angiogenic Pathways
description In this study, glioblastoma inhibition was acheived via the disruption of IL17A, which blocks angiogenesis using new derivatives of rosmarinic acid (RA). Anti-GBM activity of the compounds were determined through cell migration and cell proliferation assays with U87 MG, DBTRG MG, and EA.hy 926 cells. Antiangiogenic activity was investigated with tube formation, CAM, and aortic explant assays. The compounds’ activity in IL17A and VEGF expression was determined using ELISA and their apoptotic activity was assessed by the Caspase assay. The cancer pathway was determined using the reporter gene assay.
format Thesis
author Khan, Md Shamsuddin Sultan
author_facet Khan, Md Shamsuddin Sultan
author_sort Khan, Md Shamsuddin Sultan
title The Development Of Rosmarinic Acid Derivatives To Target Il17a In Glioblastoma Multiforme Via Angiogenic Pathways
title_short The Development Of Rosmarinic Acid Derivatives To Target Il17a In Glioblastoma Multiforme Via Angiogenic Pathways
title_full The Development Of Rosmarinic Acid Derivatives To Target Il17a In Glioblastoma Multiforme Via Angiogenic Pathways
title_fullStr The Development Of Rosmarinic Acid Derivatives To Target Il17a In Glioblastoma Multiforme Via Angiogenic Pathways
title_full_unstemmed The Development Of Rosmarinic Acid Derivatives To Target Il17a In Glioblastoma Multiforme Via Angiogenic Pathways
title_sort development of rosmarinic acid derivatives to target il17a in glioblastoma multiforme via angiogenic pathways
publishDate 2017
url http://eprints.usm.my/47701/1/THE%20DEVELOPMENT%20OF%20ROSMARINIC%20ACID.pdf%20cut.pdf
http://eprints.usm.my/47701/
_version_ 1681490250987208704
score 13.209306

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