Evaluation Of The Hepatoprotective Effects Of Tocotrienols An The Relationship Between Non-Alcoholic Fatty Liver And Brain White-Matter Lesions

• Main Author: Magosso, Enrico
• Format: Thesis
• Language: English
• Published: 2011
• Subjects: RS1-441 Pharmacy and materia medica
• Online Access: http://eprints.usm.my/45705/1/Enrico%20Magosso_HJ.pdf; http://eprints.usm.my/45705/

Non-alcoholic fatty liver disease is one of the most common liver disorders worldwide. However, no data from systematic studies are available for Malaysia on prevalence or rate of this disease. In the present study 180 walk-in mildly hypercholesterolemic adults of both genders were screened using ultrasound imaging to determine the presence of non-alcoholic fatty liver. The rate of this hepatic disease was found to be high, since it was diagnosed in almost 60% of the participants. Non-alcoholic fatty liver disease consists of fat infiltration in the liver, at present no pharmacological treatment is available. The screening was part of the recruitment process for a double-blind placebocontrolled study aimed at evaluating the activity of tocotrienols for the treatment of non-alcoholic fatty liver disease. Tocotrienols, that are extracted from palm oil, are members of the vitamin E family. Evaluation of the effects of tocotrienols for treatment of non-alcoholic fatty liver disease was performed by comparing liver echogenicity at baseline and at conclusion of the study. Liver hyperechogenicity is proportional to the fat content.