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Interaction Between Murine Cardiac Stem Cells And Bone Marrow-Derived Mesenchymal Stem Cells For Cardiomyocyte Differentiation In Vitro

Background: Bone marrow-derived mesenchymal stem cells (MSCs) has been shown to facilitate heart repair via activation of endogenous cardiac stem cells (CSCs) following infarction, but little is known if the synergy of the two cells can be exploited in vitro prior to transplantation. Objective: This...

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Main Author: Leong, Yin Yee
Format: Thesis
Language:English
Published: 2016
Subjects:
R735-854 Medical education. Medical schools. Research
Online Access:http://eprints.usm.my/45006/1/LEONG%20YIN%20YEE.pdf
http://eprints.usm.my/45006/
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spelling my.usm.eprints.45006 http://eprints.usm.my/45006/ Interaction Between Murine Cardiac Stem Cells And Bone Marrow-Derived Mesenchymal Stem Cells For Cardiomyocyte Differentiation In Vitro Leong, Yin Yee R735-854 Medical education. Medical schools. Research Background: Bone marrow-derived mesenchymal stem cells (MSCs) has been shown to facilitate heart repair via activation of endogenous cardiac stem cells (CSCs) following infarction, but little is known if the synergy of the two cells can be exploited in vitro prior to transplantation. Objective: This study aimed to examine the synergistic effects of MSCs on CSC cardiomyocyte differentiation. Methods: C-kit CSCs and MSCs were isolated from 4-6 weeks C57BL/6N mice (n=9). CSC cardiomyocyte differentiation was tested after re-isolated from MSC co-culture using micron-sized particles of iron oxide, and compared to CSCs treated with MSC-conditioned medium (CdM) or without any treatment. 2016-01 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/45006/1/LEONG%20YIN%20YEE.pdf Leong, Yin Yee (2016) Interaction Between Murine Cardiac Stem Cells And Bone Marrow-Derived Mesenchymal Stem Cells For Cardiomyocyte Differentiation In Vitro. Masters thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic R735-854 Medical education. Medical schools. Research
spellingShingle R735-854 Medical education. Medical schools. Research
Leong, Yin Yee
Interaction Between Murine Cardiac Stem Cells And Bone Marrow-Derived Mesenchymal Stem Cells For Cardiomyocyte Differentiation In Vitro
description Background: Bone marrow-derived mesenchymal stem cells (MSCs) has been shown to facilitate heart repair via activation of endogenous cardiac stem cells (CSCs) following infarction, but little is known if the synergy of the two cells can be exploited in vitro prior to transplantation. Objective: This study aimed to examine the synergistic effects of MSCs on CSC cardiomyocyte differentiation. Methods: C-kit CSCs and MSCs were isolated from 4-6 weeks C57BL/6N mice (n=9). CSC cardiomyocyte differentiation was tested after re-isolated from MSC co-culture using micron-sized particles of iron oxide, and compared to CSCs treated with MSC-conditioned medium (CdM) or without any treatment.
format Thesis
author Leong, Yin Yee
author_facet Leong, Yin Yee
author_sort Leong, Yin Yee
title Interaction Between Murine Cardiac Stem Cells And Bone Marrow-Derived Mesenchymal Stem Cells For Cardiomyocyte Differentiation In Vitro
title_short Interaction Between Murine Cardiac Stem Cells And Bone Marrow-Derived Mesenchymal Stem Cells For Cardiomyocyte Differentiation In Vitro
title_full Interaction Between Murine Cardiac Stem Cells And Bone Marrow-Derived Mesenchymal Stem Cells For Cardiomyocyte Differentiation In Vitro
title_fullStr Interaction Between Murine Cardiac Stem Cells And Bone Marrow-Derived Mesenchymal Stem Cells For Cardiomyocyte Differentiation In Vitro
title_full_unstemmed Interaction Between Murine Cardiac Stem Cells And Bone Marrow-Derived Mesenchymal Stem Cells For Cardiomyocyte Differentiation In Vitro
title_sort interaction between murine cardiac stem cells and bone marrow-derived mesenchymal stem cells for cardiomyocyte differentiation in vitro
publishDate 2016
url http://eprints.usm.my/45006/1/LEONG%20YIN%20YEE.pdf
http://eprints.usm.my/45006/
_version_ 1643711166586814464
score 13.160551

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