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Screening And Characterisation Of Inhibitors For Glyoxylate Cycle ICL Enzyme Activity In Candida Albicans

Candida albicans is an opportunistic pathogen that causes candidiasis in human. Metabolic pathways have been recently explored as potential antimicrobial targets, for example glyoxylate cycle that enables the C. albicans to servive nutrient-limited niches. Glyoxylate cycle and its key enzymes would...

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Main Author: Cheah, Hong Leong
Format: Thesis
Language:English
Published: 2014
Subjects:
R735-854 Medical education. Medical schools. Research
Online Access:http://eprints.usm.my/44992/1/CHEAH%20HONG%20LEONG.pdf
http://eprints.usm.my/44992/
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spelling my.usm.eprints.44992 http://eprints.usm.my/44992/ Screening And Characterisation Of Inhibitors For Glyoxylate Cycle ICL Enzyme Activity In Candida Albicans Cheah, Hong Leong R735-854 Medical education. Medical schools. Research Candida albicans is an opportunistic pathogen that causes candidiasis in human. Metabolic pathways have been recently explored as potential antimicrobial targets, for example glyoxylate cycle that enables the C. albicans to servive nutrient-limited niches. Glyoxylate cycle and its key enzymes would be an attractive antifungal drug target for C. albicans. In this study, an alternative cell-based screening approach that better reflect the physiological environment in host system was employed to identify lead compounds that inhibit the glyoxylate cycle. 2014-06 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/44992/1/CHEAH%20HONG%20LEONG.pdf Cheah, Hong Leong (2014) Screening And Characterisation Of Inhibitors For Glyoxylate Cycle ICL Enzyme Activity In Candida Albicans. Masters thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic R735-854 Medical education. Medical schools. Research
spellingShingle R735-854 Medical education. Medical schools. Research
Cheah, Hong Leong
Screening And Characterisation Of Inhibitors For Glyoxylate Cycle ICL Enzyme Activity In Candida Albicans
description Candida albicans is an opportunistic pathogen that causes candidiasis in human. Metabolic pathways have been recently explored as potential antimicrobial targets, for example glyoxylate cycle that enables the C. albicans to servive nutrient-limited niches. Glyoxylate cycle and its key enzymes would be an attractive antifungal drug target for C. albicans. In this study, an alternative cell-based screening approach that better reflect the physiological environment in host system was employed to identify lead compounds that inhibit the glyoxylate cycle.
format Thesis
author Cheah, Hong Leong
author_facet Cheah, Hong Leong
author_sort Cheah, Hong Leong
title Screening And Characterisation Of Inhibitors For Glyoxylate Cycle ICL Enzyme Activity In Candida Albicans
title_short Screening And Characterisation Of Inhibitors For Glyoxylate Cycle ICL Enzyme Activity In Candida Albicans
title_full Screening And Characterisation Of Inhibitors For Glyoxylate Cycle ICL Enzyme Activity In Candida Albicans
title_fullStr Screening And Characterisation Of Inhibitors For Glyoxylate Cycle ICL Enzyme Activity In Candida Albicans
title_full_unstemmed Screening And Characterisation Of Inhibitors For Glyoxylate Cycle ICL Enzyme Activity In Candida Albicans
title_sort screening and characterisation of inhibitors for glyoxylate cycle icl enzyme activity in candida albicans
publishDate 2014
url http://eprints.usm.my/44992/1/CHEAH%20HONG%20LEONG.pdf
http://eprints.usm.my/44992/
_version_ 1643711163375026176
score 13.18916

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