A Study Of The Genetic Variations In N-Terminus, C-Terminus And Promoter Of Rb1 Gene Among Retinoblastoma Patients In Malaysia
Retinoblastoma (RB) is the most common primary intraocular tumor affecting mainly children under five years of age, with a prevalence of 1 in 15 000 to 20 000 live births. Retinoblastoma is divided into hereditary and sporadic types. It is caused by mutations or changes in RB1 gene, a tumor suppress...
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| Format: | Thesis |
| Language: | English |
| Published: |
2012
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| Subjects: | |
| Online Access: | http://eprints.usm.my/44906/1/SITI%20NORULHUDA%20BT%20HAJI%20DRAMAN%20%40%20HASHIM.pdf http://eprints.usm.my/44906/ |
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| Summary: | Retinoblastoma (RB) is the most common primary intraocular tumor affecting mainly children under five years of age, with a prevalence of 1 in 15 000 to 20 000 live births. Retinoblastoma is divided into hereditary and sporadic types. It is caused by mutations or changes in RB1 gene, a tumor suppressor gene. The aim of this study is to detect mutations in N-terminus, C-terminus and promoter region of RB1 gene in retinoblastoma patients in Malaysia, as well as its association with staging and laterality of the patients. A total of 68 children with sporadic RB from Hospital Universiti Sains Malaysia (HUSM), Hospital Kuala Lumpur (HKL) and University Malaya Medical Centre (UMMC) and 68 healthy ethnic-matched controls were recruited. |
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