Biosynthesis Of Endosome-Specific Lipid Bis(Monoacylglycero)Phosphate

The hypothetical de novo biosynthetic pathway of endosome-specific phospholipid, bis(monoacylglycero)phosphate (BMP) from endogenous phosphatidylglycerol (PG) precursor via lysophosphatidylglycerol (LPG) intermediate had been considered. In the present study, an alternative BMP biosynthetic route fr...

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Main Author: Lim,, Shi Rou
Format: Thesis
Language:English
Published: 2018
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Online Access:http://eprints.usm.my/44253/1/LIM%20SHI%20ROU.pdf
http://eprints.usm.my/44253/
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spelling my.usm.eprints.44253 http://eprints.usm.my/44253/ Biosynthesis Of Endosome-Specific Lipid Bis(Monoacylglycero)Phosphate Lim,, Shi Rou RS1-441 Pharmacy and materia medica The hypothetical de novo biosynthetic pathway of endosome-specific phospholipid, bis(monoacylglycero)phosphate (BMP) from endogenous phosphatidylglycerol (PG) precursor via lysophosphatidylglycerol (LPG) intermediate had been considered. In the present study, an alternative BMP biosynthetic route from PG via acylphosphatidylglycerol (AcPG) intermediate was proposed. A considerable amount of AcPG was found present in and outside the RAW 264.7 cells during 24 hours of incubation with exogenous PG. A transacylase is required to transfer an acyl chain from a PG donor to a PG acceptor, transforming the acceptor PG into AcPG and the donor PG into LPG. 2018-03 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/44253/1/LIM%20SHI%20ROU.pdf Lim,, Shi Rou (2018) Biosynthesis Of Endosome-Specific Lipid Bis(Monoacylglycero)Phosphate. PhD thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic RS1-441 Pharmacy and materia medica
spellingShingle RS1-441 Pharmacy and materia medica
Lim,, Shi Rou
Biosynthesis Of Endosome-Specific Lipid Bis(Monoacylglycero)Phosphate
description The hypothetical de novo biosynthetic pathway of endosome-specific phospholipid, bis(monoacylglycero)phosphate (BMP) from endogenous phosphatidylglycerol (PG) precursor via lysophosphatidylglycerol (LPG) intermediate had been considered. In the present study, an alternative BMP biosynthetic route from PG via acylphosphatidylglycerol (AcPG) intermediate was proposed. A considerable amount of AcPG was found present in and outside the RAW 264.7 cells during 24 hours of incubation with exogenous PG. A transacylase is required to transfer an acyl chain from a PG donor to a PG acceptor, transforming the acceptor PG into AcPG and the donor PG into LPG.
format Thesis
author Lim,, Shi Rou
author_facet Lim,, Shi Rou
author_sort Lim,, Shi Rou
title Biosynthesis Of Endosome-Specific Lipid Bis(Monoacylglycero)Phosphate
title_short Biosynthesis Of Endosome-Specific Lipid Bis(Monoacylglycero)Phosphate
title_full Biosynthesis Of Endosome-Specific Lipid Bis(Monoacylglycero)Phosphate
title_fullStr Biosynthesis Of Endosome-Specific Lipid Bis(Monoacylglycero)Phosphate
title_full_unstemmed Biosynthesis Of Endosome-Specific Lipid Bis(Monoacylglycero)Phosphate
title_sort biosynthesis of endosome-specific lipid bis(monoacylglycero)phosphate
publishDate 2018
url http://eprints.usm.my/44253/1/LIM%20SHI%20ROU.pdf
http://eprints.usm.my/44253/
_version_ 1643710954813259776
score 13.211869