Changes In Central And Peripheral Regulation Of Streptozotocin-Induced Diabetic Rats

• Main Author: Hassan, Zurina
• Format: Thesis
• Language: English
• Published: 2012
• Subjects: RS1-441 Pharmacy and materia medica
• Online Access: http://eprints.usm.my/42894/1/ZURINA_HASSAN.pdf; http://eprints.usm.my/42894/

Alterations of cardiovascular reflexes in diabetes contribute to the increased cardiovascular morbidity and mortality. These alterations may be mediated at the level of afferent nerves, central baroreflex or efferent nerves within the baroreflex circuitry. Using the streptozotocin (STZ)-induced diabetic rats, the current study was designed to: (1) examine systematically diabetes-induced alteration of the multiple neural components by investigating the afferent nerves of the baroreceptor reflex, contribution of the central baroreflex in the rostral ventrolateral medulla (RVLM) and paraventricular nucleus (PVN) and distribution of activated neurons (c-Fos) in response to baroreceptor activation; (2) evaluate the vascular responsiveness of the diabetic pithed rats in the absence of baroreflex; and (3) examine the potential cellular mechanisms in isolated in vitro aortic rings that may contribute to vascular dysfunction.