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Focal Adhesion Kinase (FAK) is a 125 kDa non-receptor protein tyrosine kinase. FAK plays a pivotal role in the regulation of various cellular activities such as migration, adhesion, proliferation and growth. It has been reported that FAK has dual function as a scaffold and kinase protein. Analyses a...

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Bibliographic Details
Main Author: Majeed, Saif Aldin R. Abdul
Format: Thesis
Language:English
Published: 2011
Subjects:
Online Access:http://eprints.usm.my/42513/1/SALEH_M.S._OMARI.pdf
http://eprints.usm.my/42513/
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Summary:Focal Adhesion Kinase (FAK) is a 125 kDa non-receptor protein tyrosine kinase. FAK plays a pivotal role in the regulation of various cellular activities such as migration, adhesion, proliferation and growth. It has been reported that FAK has dual function as a scaffold and kinase protein. Analyses at the protein and cellular levels have demonstrated FAK overexpression and phosphorylation at specific residues in many tumours; however the data were mostly inconclusive and need further investigation.