A study on the protective effects of calcium channel blockers against anoxic brain damage
Introduction It is now widely accepted that a rapid neuronal influx of Ca2+ following cerebral ischaemia! hypoxia is intimately connected with the cascade of events- including activation of enzymes which give rise to the production of reactive oxygen species and nitric oxide, thereby leading to f...
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| Main Authors: | , , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
1997
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| Subjects: | |
| Online Access: | http://eprints.usm.my/42325/1/GP...A_Study_On_The_Protective_Effects_Of_Calcium_Channel_Blockers_Against_Anoxic_Brain_Damage...OCR.pdf http://eprints.usm.my/42325/ |
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| Summary: | Introduction
It is now widely accepted that a rapid neuronal influx of Ca2+ following cerebral ischaemia!
hypoxia is intimately connected with the cascade of events- including activation of enzymes which give
rise to the production of reactive oxygen species and nitric oxide, thereby leading to free-radical induced
damage -which reseult in neuronal injury and death. It is also known that a burst of free radical generation
I
occurs during re-oxygenation of the tissues following a period,ofischaernialhypoxia as also a prolonged
purturbation of the membrane functions continues after the perfusion/oxygenation has been restored, which
leads to continued accumulnnon of calcium intracellularly ; resulting ultimately in delayed damage and death
of the neurone.
Estimation of lipid peroxidation products proviqes a reliable estimate of free radical induced damage to
tissues, and has been widely used for this purpose. |
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