Effects of Tualang Honey on Memory Performance, Depressive-like Behaviour, Histological and Biochemical Changes in Young and Old Male Rats Exposed to Loud Noise Stress

• Main Author: Azman, Khairunnuur Fairuz
• Format: Thesis
• Language: English
• Published: 2016
• Subjects: R5-920 Medicine (General)
• Online Access: http://eprints.usm.my/40850/1/Dr._Khairunnuur_Fairuz_Azman_TSTZ.pdf; http://eprints.usm.my/40850/

Penuaan dan pendedahan kepada tekanan boleh menyumbang kepada kemerosotan ingatan dan kemurungan manakala stres oksidatif merupakan salah satu mekanisme yang mungkin terlibat. Pencarian penambahbaik fungsi kognitif daripada derivatif produk semulajadi yang mengandungi antioksidan semakin mendapat perhatian. Oleh itu, kajian ini bertujuan untuk memeriksa kesan penuaan dan tekanan ke atas prestasi ingatan dan tingkahlaku seperti kemurungan, dan menjelaskan kemungkinan mekanisme sandaran keberkesanan terapeutik madu Tualang dalam menambahbaikkan prestasi ingatan dan simptom kemurungan pada tikus jantan muda dan tua yang terdedah kepada tekanan bunyi bising. Ageing and stress exposure may lead to memory impairment and depression while oxidative stress is thought to be one of the underlying mechanisms involved. The search for cognitive enhancers from natural products derivatives possessing antioxidants has gained much attention. Thus, this study aimed to examine the effects of ageing and stress on memory performance and depressive-like behaviour, and to elucidate the possible mechanisms underlying therapeutic efficacy of Tualang honey in improving memory performance and depressive symptoms in young and old male rats exposed to loud noise stress.