Evaluation of the potential of Mycobacterium smegmatis as vaccine Candidate against tuberculosis by in silico and in vivo studies

• Main Authors: Nguyen Thi, Le Thuy, Maura, Reinier Borrero, Férnandez, Sonsire, Reyes, Giselle, Perez, José Luis, Reyes, Fátima, García, María de los Angeles, Fariñas, Midrey, Infante, Juan Francisco, Tirado, Yanely, Puig, Alina, Sierra, Gustavo, Álvarez, Nadine, Ramírez, Juan Carlos, Sarmiento, María Elena, Norazmi, Mohd Nor, Acosta, Armando
• Format: Article
• Language: English
• Published: Finlay Ediciones 2010
• Subjects: R5-920 Medicine (General)
• Online Access: http://eprints.usm.my/39018/1/Evaluation_of_the_potential_of_Mycobacterium_smegmatis_as_vaccine_Candidate_against_tuberculosis_by_in_silico_and_in_vivo_studies.pdf; http://eprints.usm.my/39018/; https://doaj.org/article/2cf44e356c0d4703be0b33c7095b10c1

In this study, we scanned multiple published databases of gene expression in vivo of M. tuberculosis at different phases of infection in animals and humans, to select 38 proteins that are highly expressed in the active, latent and reactivation phases. The selected proteins were predicted for T and...