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Clinacanthus nutans Extracts Are Antioxidant with Antiproliferative Effect on Cultured Human Cancer Cell Lines

Clinacanthus nutans Lindau leaves (CN) have been used in traditionalmedicine but the therapeutic potential has not been explored for cancer prevention and treatment. Current study aimed to evaluate the antioxidant and antiproliferative effects of CN, extracted in chloroform, methanol, and water, o...

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Main Authors: Yoke, Keong Yong, Jun, Jie Tan, Soek, Sin Teh, Siau, Hui Mah, Cheng, Gwendoline Lian Ee, Hoe, Siong Chiong, Ahmad, Zuraini
Format: Article
Language:English
Published: Hindawi Publishing Corporation 2013
Subjects:
RK1-715 Dentistry
Online Access:http://eprints.usm.my/38453/1/Clinacanthus_nutans_Extracts_Are_Antioxidant_with_Antiproliferative_Effect_on_Cultured_Human.pdf
http://eprints.usm.my/38453/
http://dx.doi.org/10.1155/2013/462751
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spelling my.usm.eprints.38453 http://eprints.usm.my/38453/ Clinacanthus nutans Extracts Are Antioxidant with Antiproliferative Effect on Cultured Human Cancer Cell Lines Yoke, Keong Yong Jun, Jie Tan Soek, Sin Teh Siau, Hui Mah Cheng, Gwendoline Lian Ee Hoe, Siong Chiong Ahmad, Zuraini RK1-715 Dentistry Clinacanthus nutans Lindau leaves (CN) have been used in traditionalmedicine but the therapeutic potential has not been explored for cancer prevention and treatment. Current study aimed to evaluate the antioxidant and antiproliferative effects of CN, extracted in chloroform, methanol, and water, on cancer cell lines. Antioxidant properties of CN were evaluated using DPPH, galvinoxyl, nitric oxide, and hydrogen peroxide based radical scavenging assays, whereas the tumoricidal effect was tested on HepG2, IMR32, NCL-H23, SNU-1, Hela, LS-174T, K562, Raji, and IMR32 cancer cells using MTT assay. Our data showed that CN in chloroform extract was a good antioxidant against DPPH and galvinoxyl radicals, but less effective in negating nitric oxide and hydrogen peroxide radicals. Chloroformextract exerted the highest antiproliferative effect on K-562 (91.28±0.03%) andRaji cell lines (88.97± 1.07%) at 100 Hindawi Publishing Corporation 2013 Article PeerReviewed application/pdf en http://eprints.usm.my/38453/1/Clinacanthus_nutans_Extracts_Are_Antioxidant_with_Antiproliferative_Effect_on_Cultured_Human.pdf Yoke, Keong Yong and Jun, Jie Tan and Soek, Sin Teh and Siau, Hui Mah and Cheng, Gwendoline Lian Ee and Hoe, Siong Chiong and Ahmad, Zuraini (2013) Clinacanthus nutans Extracts Are Antioxidant with Antiproliferative Effect on Cultured Human Cancer Cell Lines. Evidence-Based Complementary and Alternative Medicine, 2013 (462751). pp. 1-8. ISSN 1741-427X http://dx.doi.org/10.1155/2013/462751
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic RK1-715 Dentistry
spellingShingle RK1-715 Dentistry
Yoke, Keong Yong
Jun, Jie Tan
Soek, Sin Teh
Siau, Hui Mah
Cheng, Gwendoline Lian Ee
Hoe, Siong Chiong
Ahmad, Zuraini
Clinacanthus nutans Extracts Are Antioxidant with Antiproliferative Effect on Cultured Human Cancer Cell Lines
description Clinacanthus nutans Lindau leaves (CN) have been used in traditionalmedicine but the therapeutic potential has not been explored for cancer prevention and treatment. Current study aimed to evaluate the antioxidant and antiproliferative effects of CN, extracted in chloroform, methanol, and water, on cancer cell lines. Antioxidant properties of CN were evaluated using DPPH, galvinoxyl, nitric oxide, and hydrogen peroxide based radical scavenging assays, whereas the tumoricidal effect was tested on HepG2, IMR32, NCL-H23, SNU-1, Hela, LS-174T, K562, Raji, and IMR32 cancer cells using MTT assay. Our data showed that CN in chloroform extract was a good antioxidant against DPPH and galvinoxyl radicals, but less effective in negating nitric oxide and hydrogen peroxide radicals. Chloroformextract exerted the highest antiproliferative effect on K-562 (91.28±0.03%) andRaji cell lines (88.97± 1.07%) at 100
format Article
author Yoke, Keong Yong
Jun, Jie Tan
Soek, Sin Teh
Siau, Hui Mah
Cheng, Gwendoline Lian Ee
Hoe, Siong Chiong
Ahmad, Zuraini
author_facet Yoke, Keong Yong
Jun, Jie Tan
Soek, Sin Teh
Siau, Hui Mah
Cheng, Gwendoline Lian Ee
Hoe, Siong Chiong
Ahmad, Zuraini
author_sort Yoke, Keong Yong
title Clinacanthus nutans Extracts Are Antioxidant with Antiproliferative Effect on Cultured Human Cancer Cell Lines
title_short Clinacanthus nutans Extracts Are Antioxidant with Antiproliferative Effect on Cultured Human Cancer Cell Lines
title_full Clinacanthus nutans Extracts Are Antioxidant with Antiproliferative Effect on Cultured Human Cancer Cell Lines
title_fullStr Clinacanthus nutans Extracts Are Antioxidant with Antiproliferative Effect on Cultured Human Cancer Cell Lines
title_full_unstemmed Clinacanthus nutans Extracts Are Antioxidant with Antiproliferative Effect on Cultured Human Cancer Cell Lines
title_sort clinacanthus nutans extracts are antioxidant with antiproliferative effect on cultured human cancer cell lines
publisher Hindawi Publishing Corporation
publishDate 2013
url http://eprints.usm.my/38453/1/Clinacanthus_nutans_Extracts_Are_Antioxidant_with_Antiproliferative_Effect_on_Cultured_Human.pdf
http://eprints.usm.my/38453/
http://dx.doi.org/10.1155/2013/462751
_version_ 1643709361923555328
score 13.211869

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