Attributable causes of chronic kidney disease in adults: a five-year retrospective study in a tertiary-care hospital in the northeast of the Malaysian Peninsula
CONTEXT AND OBJECTIVE: Chronic kidney disease (CKD) is an escalating medical and socioeconomic problem worldwide. Information concerning the causes of CKD, which is a prerequisite for reducing the disease burden, is sparse in Malaysia. Therefore, this study aimed to evaluate the attributable cause...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Associação Paulista de Medicina
2015
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| Subjects: | |
| Online Access: | http://eprints.usm.my/38376/1/Attributable_causes_of_chronic_kidney_disease_in_adults.pdf http://eprints.usm.my/38376/ https://www.ncbi.nlm.nih.gov/pubmed/26760124 |
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| Summary: | CONTEXT AND OBJECTIVE: Chronic kidney disease (CKD) is an escalating medical and socioeconomic
problem worldwide. Information concerning the causes of CKD, which is a prerequisite for reducing the
disease burden, is sparse in Malaysia. Therefore, this study aimed to evaluate the attributable causes of CKD
in an adult population at a tertiary referral hospital.
DESIGN AND SETTING: Retrospective study at Hospital Universiti Sains Malaysia (HUSM).
METHODS: This was an analysis based on medical records of adult patients at HUSM. Data regarding demographics,
laboratory investigations, attributable causes and CKD stage were gathered.
RESULTS: A total of 851 eligible cases were included. The patients’ mean age was 61.18 ± 13.37 years. CKD
stage V was found in 333 cases (39.1%) whereas stages IV, IIIb, IIIa, and II were seen in 240 (28.2%), 186 (21.9%),
74 (8.7%) and 18 (2.1%), respectively. The percentage of CKD stage V patients receiving renal replacement
therapy was 15.6%. The foremost attributable causes of CKD were diabetic nephropathy (DN) (44.9%), hypertension
(HPT) (24.2%) and obstructive uropathy (9.2%). The difference in the prevalence of CKD due to DN,
HPT and glomerulonephritis between patients ≤ 50 and > 50 years old was statistically significant.
CONCLUSION: Our results suggest that DN and HPT are the major attributable causes of CKD among
patients at a Malaysian tertiary-care hospital. Furthermore, the results draw attention to the possibility that
greater emphasis on primary prevention of diabetes and hypertension will have a great impact on reduction
of hospital admissions due to CKD in Malaysia. |
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