3,5-Bis(arylidene)-4-piperidones as potential dengue protease inhibitors

• Main Authors: Osman, Hasnah, Idris, Nor Hashima, Kamarulzaman, Ezatul Ezleen, A. Wahab, Habibah, Hassan, Mohd. Zaheen
• Format: Article
• Published: Elsevier 2017
• Subjects: QD1-999 Chemistry; RS1-441 Pharmacy and materia medica
• Online Access: http://eprints.usm.my/37959/; http://dx.doi.org/10.1016/j.apsb.2017.04.009

Dengue is a severe mosquito-borne viral in fection causing half a million deaths annually. Dengue virusNS2B/NS3 protease is a validated target for anti-dengue drug design. A series of hitherto unreported 3,5-bis(arylidene)-4-piperidones analogues 4a–4j were synthesized and screened in silico against...