Inhibitory Effects of Tualang Honey on Experimental Breast Cancer in Rats: A Preliminary Study
The study was conducted to determine the effect of Malaysian jungle Tualang Honey (TH) on development of breast cancer induced by the carcinogen 7,12-dimethylbenz(α)anthracene (DMBA) in rats. Forty nulliparous female Sprague-Dawley rats were given 80 mg/kg DMBA then randomly divided into four grou...
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Format: | Article |
Language: | English |
Published: |
Asian Pacific Organization for Cancer Prevetion
2013
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Subjects: | |
Online Access: | http://eprints.usm.my/37322/1/POCPA9_2013_v14n4_2249.pdf http://eprints.usm.my/37322/ http://www.koreascience.or.kr/article/ArticleFullRecord.jsp?cn=POCPA9_2013_v14n4_2249 |
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Summary: | The study was conducted to determine the effect of Malaysian jungle Tualang Honey (TH) on development
of breast cancer induced by the carcinogen 7,12-dimethylbenz(α)anthracene (DMBA) in rats. Forty nulliparous
female Sprague-Dawley rats were given 80 mg/kg DMBA then randomly divided into four groups: Group 1
served as a Control while Groups 2, 3 and 4 received 0.2, 1.0 or 2.0 g/kg bodyweight/day of TH, respectively, for
150 days. Results showed that breast cancers in the TH-treated groups had slower size increment and smaller
mean tumor size (≤2cm3
) compared to Controls (≤8cm3
). The number of cancers developing in TH-treated groups
was also significantly fewer (P<0.05). Histological grading showed majority of TH–treated group cancers to be
of grade 1 and 2 compared to grade 3 in controls. There was an increasing trend of apoptotic index (AI) seen
in TH-treated groups with increasing dosage of Tualang Honey, however, the mean AI values of all TH-treated
groups were not significantly different from the Control value (p>0.05). In conclusion, Tualang Honey exerted
positive modulation effects on DMBA-induced breast cancers in rats in this preliminary study |
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