Tetracaine – selective electrodes with polymer membranes and their application in pharmaceutical formulation control
The construction and electrochemical response characteristics of poly(vinyl chloride) (PVC) membrane electrodes for tetracaine hydrochloride (TCH) are described. The sensing membranes incorporating ion-association complexes of tetracaine cation with phosphotungstic acid (PTA) or phosphomolybdic a...
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| Main Authors: | , , |
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| Format: | Article |
| Published: |
Elsevier
2017
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| Subjects: | |
| Online Access: | http://eprints.usm.my/37245/ https://doi.org/10.1016/j.arabjc.2013.04.029 |
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| Summary: | The construction and electrochemical response characteristics of poly(vinyl chloride)
(PVC) membrane electrodes for tetracaine hydrochloride (TCH) are described. The sensing membranes
incorporating ion-association complexes of tetracaine cation with phosphotungstic acid
(PTA) or phosphomolybdic acid (PMA) or Sodium tetraphenyl borate (NaTPB) as electroactive
materials and di-n-butyl phthalate (DBPH) or tri-n-butyl phosphate (TBP) as a plasticizer in
PVC matrixes were evaluated. The results obtained show the electrodes based on PTA or PMA
as electroactive compounds and DBPH as plasticizer with a fast, stable and near-Nernstian
response over a wide concentration range (1 · 10�5–5 · 10�2 M), with cationic slopes of 55.02
and 52.05 mV decade�1 over a pH range of (2.5–6.5). The electrodes show good discrimination
of tetracaine from several inorganic cations and sugars. The electrodes were successfully applied
for the determination of tetracaine in pharmaceutical formulations. |
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