Synthesis and Evaluation of N-(3-Trifluoroacetylindol- 7-yl) Acetamides for Potential In Vitro Antiplasmodial Properties

• Main Authors: Malose J., Mphahlele, Mmakwena M., Mmonwa, Yee, Siew Choong
• Format: Article
• Language: English
• Published: MDPI 2017
• Subjects: R735-854 Medical education. Medical schools. Research
• Online Access: http://eprints.usm.my/37238/1/%28Synthesis_and_Evaluation%29_molecules-22-01099.pdf; http://eprints.usm.my/37238/; http://www.mdpi.com/1420-3049/22/7/1099

A series of novel N-((2,5-diaryl-3-trifluoroacetyl)-1H-indol-7-yl)acetamides has been prepared via a successive and one-pot reaction sequence involving initial trifluoroacetic acid-mediated Beckmann rearrangement of the oximes derived from the 1-(2,5-diaryl-1H-indol-7-yl)ethanones, followed by tr...