Gene expression profile of primary fibroblasts from keloid and normal skin treated with palm oil tocotrienol rich fraction (TRF)

• Main Author: Kamarulzaman, Siti Arffah
• Format: Thesis
• Language: English
• Published: 2013
• Subjects: R5-130.5 General works
• Online Access: http://eprints.usm.my/36420/1/Dr._Siti_Arefah_Kamarulzaman_TSTZ_%28NN24%29.pdf; http://eprints.usm.my/36420/

Keloid adalah penyakit kulit fibroproliferatif yang terbentuk disebabkan oleh tindak balas luka yang tidak normal pada individu tertentu. Perubahan terhadap faktor pertumbuhan dan sitokin dalam proses penyembuhan yang tidak normal membentuk keadaan yang tidak seimbang antara sintesis dan degradasi kolagen dan komponen ekstraselular matriks yang lain. Pelbagai rawatan telah dicuba untuk keloid, tetapi secara klinikal, kebanyakan terapi masih tidak memuaskan. Kepentingan saintifik tokotrienol telah meningkat kerana sifatnya sebagai antioksida dan sifat berkaitan pelindung. Walau bagaimanapun, terdapat kekurangan bukti saintifik mengenai keberkesanan tokotrienol dalam pengurusan keloid dan parut. Oleh itu, kajian ini telah dijalankan untuk menyiasat kesan-kesan berfaedah pecahan tokotrienol (TRF) minyak kelapa sawit pada fibroblas keloid. Keloids are dermal fibroproliferative disease that developed due to abnormal wound response in predisposed individuals. The alteration of growth factors and cytokines in abnormal healing process formed an imbalanced condition between collagen and other extracellular matrix components synthesis and degradation. Various treatments for keloids have been tried but most of the therapeutic approaches remain clinically unsatisfactory. Tocotrienols have gained increasing scientific interest due to their antioxidant and related protective properties. However, there is lack of scientific evidence regarding the efficacy and therapies of tocotrienol in keloid and scar management. Thus, this study was carried out to investigate the effects of palm oil tocotrienol rich fraction (TRF) on human keloid fibroblasts. Keloids and normal skin were collected as samples in this study.