Validation of international prognostic index for non-hodgkin's lymphoma in northeast Peninsular Malaysian Malays

• Main Author: Abdullah, Abu Dzarr Ganesh
• Format: Thesis
• Language: English
• Published: 2002
• Subjects: R5-130.5 General works
• Online Access: http://eprints.usm.my/36044/1/Dr_Abu_Dzarr_Ganesh_Abdullah_-_TNM_%28NN1%2924.pdf; http://eprints.usm.my/36044/

Indeks Prognosis Antarabangsa {IPI) telah diketengahkan untuk menstratumkan risiko pesakit limfoma bukan Hodgkin (NHL) dan mengenalpasti subset pesakit berisiko tinggi yang mungkin tidak dapat bertindakbalas terhadap kemoterapi dengan memuaskan. IPI telah dibentuk berlandaskan model populasi pesakit berbangsa barat. Kami telah menlaksanakan suatu kajian longitudinal melibatkan pesakit NHL aggresif yang menerima rawatan di Hospital USM dari I haribulan J anuari 1990 ke 31 haribulan Disember 2000. Kajian ini hanya melibatkan pesakit berbangsa Melayu. Ini bertujuan untuk menguji kesesuaian penggunaan IPI ke atas etnik tersebut. Ciri-ciri klinikal sepertimana yang telah diuji dalam model IPI yang asal, telah diuji ke atas kohort kami. Pencapaian pesakit dari segi kadar respons sempurna (complete response rate : CR), kadar kemandirian keseluruhan (overall survival rate: OS) dan kadar kemandirian bebas penyakit (disease free survival rate: DFS) bagi setiap faktor eli atas telah eli olah. Pada masa yang sama data-data yang diperolehi telah digunakan untuk membentuk profit penyakit NHL dalam populasi kami. International prognostic index (IPI) was introduced to risk stratify non-Hodgkin lymphoma (NHL) patients and to identify high-risk patient who might not respond favorably to standard chemotherapy. IPI was modeled from a Caucasian based patient population. We undertook a single center, observational longitudinal study involving all available patients with aggressive NHL who had received treatment from Hospital USM between 1st Jan 1990 and 31st Dec 2000. We confined our study to adult Malay patients to test the applicability of IPI in this racial group. Individual presenting clinical features was categorized as in the IPI study, and the patients' outcome in terms of complete response (CR), overall survival (OS) and disease free survival (DFS) rates for each of the above features were determined. At the same time the available data was used to characterize NHL disease profile in our patient population.