Alkaloids from the roots of Stemona javanica (Kunth) Engl. (Stemonaceae) and their anti-malarial, acetylcholinesterase inhibitory and cytotoxic activities

• Main Authors: R.A., Ramli,, P., Pudjiastuti,, T.S., Tjahjandaric,, W., Lie,, R., Rattanajak,, S., Kamchonwongapaisan,, S.G., Pyne,
• Format: Article
• Language: en_US
• Published: Elsevier Ltd 2015
• Subjects: Anti-malarial; Cytotoxicity; Human acetylcholinesterase; Javastemonine A and B; Stemona javanica
• Online Access: http://ddms.usim.edu.my/handle/123456789/8506

Two new protostemonine-type alkaloids, javastemonine A and B (3 and 4) have been isolated from the root extracts of Stemona javanica together with four known Stemona alkaloids, 13-demethoxy-11(S∗),12(R∗)-dihydroprotostemonine (1), isoprotostemonine (2), protostemonine and isomaistemonine. The struct...