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Alkaloids from the roots of Stemona javanica (Kunth) Engl. (Stemonaceae) and their anti-malarial, acetylcholinesterase inhibitory and cytotoxic activities

Two new protostemonine-type alkaloids, javastemonine A and B (3 and 4) have been isolated from the root extracts of Stemona javanica together with four known Stemona alkaloids, 13-demethoxy-11(S∗),12(R∗)-dihydroprotostemonine (1), isoprotostemonine (2), protostemonine and isomaistemonine. The struct...

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Main Authors: R.A., Ramli,, P., Pudjiastuti,, T.S., Tjahjandaric,, W., Lie,, R., Rattanajak,, S., Kamchonwongapaisan,, S.G., Pyne,
格式: Article
語言:en_US
出版: Elsevier Ltd 2015
主題:
Anti-malarial
Cytotoxicity
Human acetylcholinesterase
Javastemonine A and B
Stemona javanica
在線閱讀:http://ddms.usim.edu.my/handle/123456789/8506
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spelling my.usim-85062017-02-23T03:53:20Z Alkaloids from the roots of Stemona javanica (Kunth) Engl. (Stemonaceae) and their anti-malarial, acetylcholinesterase inhibitory and cytotoxic activities R.A., Ramli, P., Pudjiastuti, T.S., Tjahjandaric, W., Lie, R., Rattanajak, S., Kamchonwongapaisan, S.G., Pyne, Anti-malarial Cytotoxicity Human acetylcholinesterase Javastemonine A and B Stemona javanica Two new protostemonine-type alkaloids, javastemonine A and B (3 and 4) have been isolated from the root extracts of Stemona javanica together with four known Stemona alkaloids, 13-demethoxy-11(S∗),12(R∗)-dihydroprotostemonine (1), isoprotostemonine (2), protostemonine and isomaistemonine. The structures and relative configurations of the new alkaloids were determined by spectroscopic analysis. The alkaloids 1 and 2 and protostemonine showed moderated antiplasmodial activities against the Plasmodium falciparum strains, TM4 (IC50 values of 17.7 ± 3.7, 16.8 ± 5.4, 16.0 ± 4.2 μg/mL, respectively) and K1 (IC50 values of 16.8 ± 3.1, 14.1 ± 3.7, 11.9 ± 3.3 μg/mL, respectively). These compounds showed no significant cytotoxicities against KB or Vero cells or acetylcholinesterase inhibitory activities. 2015-06-25T06:54:28Z 2015-06-25T06:54:28Z 2015 Article 18743900 http://ddms.usim.edu.my/handle/123456789/8506 en_US Elsevier Ltd
institution Universiti Sains Islam Malaysia
building USIM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universit Sains Islam i Malaysia
content_source USIM Institutional Repository
url_provider http://ddms.usim.edu.my/
language en_US
topic Anti-malarial
Cytotoxicity
Human acetylcholinesterase
Javastemonine A and B
Stemona javanica
spellingShingle Anti-malarial
Cytotoxicity
Human acetylcholinesterase
Javastemonine A and B
Stemona javanica
R.A., Ramli,
P., Pudjiastuti,
T.S., Tjahjandaric,
W., Lie,
R., Rattanajak,
S., Kamchonwongapaisan,
S.G., Pyne,
Alkaloids from the roots of Stemona javanica (Kunth) Engl. (Stemonaceae) and their anti-malarial, acetylcholinesterase inhibitory and cytotoxic activities
description Two new protostemonine-type alkaloids, javastemonine A and B (3 and 4) have been isolated from the root extracts of Stemona javanica together with four known Stemona alkaloids, 13-demethoxy-11(S∗),12(R∗)-dihydroprotostemonine (1), isoprotostemonine (2), protostemonine and isomaistemonine. The structures and relative configurations of the new alkaloids were determined by spectroscopic analysis. The alkaloids 1 and 2 and protostemonine showed moderated antiplasmodial activities against the Plasmodium falciparum strains, TM4 (IC50 values of 17.7 ± 3.7, 16.8 ± 5.4, 16.0 ± 4.2 μg/mL, respectively) and K1 (IC50 values of 16.8 ± 3.1, 14.1 ± 3.7, 11.9 ± 3.3 μg/mL, respectively). These compounds showed no significant cytotoxicities against KB or Vero cells or acetylcholinesterase inhibitory activities.
format Article
author R.A., Ramli,
P., Pudjiastuti,
T.S., Tjahjandaric,
W., Lie,
R., Rattanajak,
S., Kamchonwongapaisan,
S.G., Pyne,
author_facet R.A., Ramli,
P., Pudjiastuti,
T.S., Tjahjandaric,
W., Lie,
R., Rattanajak,
S., Kamchonwongapaisan,
S.G., Pyne,
author_sort R.A., Ramli,
title Alkaloids from the roots of Stemona javanica (Kunth) Engl. (Stemonaceae) and their anti-malarial, acetylcholinesterase inhibitory and cytotoxic activities
title_short Alkaloids from the roots of Stemona javanica (Kunth) Engl. (Stemonaceae) and their anti-malarial, acetylcholinesterase inhibitory and cytotoxic activities
title_full Alkaloids from the roots of Stemona javanica (Kunth) Engl. (Stemonaceae) and their anti-malarial, acetylcholinesterase inhibitory and cytotoxic activities
title_fullStr Alkaloids from the roots of Stemona javanica (Kunth) Engl. (Stemonaceae) and their anti-malarial, acetylcholinesterase inhibitory and cytotoxic activities
title_full_unstemmed Alkaloids from the roots of Stemona javanica (Kunth) Engl. (Stemonaceae) and their anti-malarial, acetylcholinesterase inhibitory and cytotoxic activities
title_sort alkaloids from the roots of stemona javanica (kunth) engl. (stemonaceae) and their anti-malarial, acetylcholinesterase inhibitory and cytotoxic activities
publisher Elsevier Ltd
publishDate 2015
url http://ddms.usim.edu.my/handle/123456789/8506
_version_ 1645152430216708096
score 13.250246

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