Antibiotic Susceptibility of Clinical Isolates of Pseudomonas Aeruginosa
Ongoing surveillance of Pseudomonas aeruginosa resistance against antimicrobial agents is fundamental to monitor trends in its susceptibility patterns and to appropriately guide clinicians in choosing empirical or directed therapy. The current in vitro activity level of eight antimicrobial drugs...
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| Format: | Research Report |
| Language: | English |
| Published: |
Universiti Sains Islam Malaysia
2011
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| Subjects: | |
| Online Access: | http://ddms.usim.edu.my/handle/123456789/4100 |
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| Summary: | Ongoing surveillance of Pseudomonas aeruginosa resistance against
antimicrobial agents is fundamental to monitor trends in its susceptibility patterns and to
appropriately guide clinicians in choosing empirical or directed therapy. The current in
vitro activity level of eight antimicrobial drugs was assessed against 97 clinical isolates
of P. aeruginosa collected consecutively for three months in 2007 from a Malaysian
hospital. Antimicrobial susceptibility was determined using the Etest method
subsequent to the hospital's routine diagnostic testing by the disk diffusion method.
Respiratory isolates, followed by wound swab isolates were the most frequently
encountered. The Etest and disk diffusion methods showed high agreement in
determining the in vitro activity of the antimicrobial agents on the P. aeruginosa
isolates. Etest results showed piperacillin-tazobactam was the most active antimicrobial
agent with 91.8% susceptibility, followed by the aminoglycosides (amikacin, 86.6% and
gentamicin, 84.5%), the quinolone (ciprofloxacin, 83.5%) and the beta-lactams
(cefepime, 80.4%, ceftazidime, 80.4%, imipenem, 79.4% and meropenem, 77.3%).
Incidence of multidrug-resistance was 19.6% (19 out of 97 isolates). The higher
resistance rate in general as compared to previous studies call for prudent use of
antibiotics in order to limit further increase in resistance. Periodical surveillance of
antibiotic resistance is fundamental to monitor changes in susceptibility patterns in a
hospital setting. A standard definition of Pseudomonas aeruginosa multidrug resistance
is crucially needed to allow better comparisons between studies. |
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