Co-inheritance of compound heterozygous Hb constant spring and a single -α 3.7 gene deletion with heterozygous δβ thalassaemia: A diagnostic challenge

• Main Authors: Azma R.Z., Othman A., Azman N., Alauddin H., Ithnin A., Yusof N., Razak N.F., Sardi N.H., Hussin N.H.
• Format: Article
• Language: English
• Published: 2017
• Subjects: α +thalassaemia; δβ; Capillary electrophoresis; Hb constant spring; Molecular analysis; Thalassaemia
• Online Access: http://ddms.usim.edu.my:80/jspui/handle/123456789/15328

Haemoglobin Constant Spring (Hb CS) mutation and single gene deletions are common underlying genetic abnormalities for alpha thalassaemias. Co-inheritance of deletional and non-deletional alpha (α) thalassaemias may result in various thalassaemia syndromes. Concomitant co-inheritance with beta (β) a...