Creatine kinase and SLCO1B1 RS4363657 polymorphism in Malaysian dyslipidaemic patients prescribed with statin drugs

• Main Author: Meor Anuar Shuhaili, Meor Fairuz Rizal
• Format: Thesis
• Language: English
• Published: 2016
• Subjects: Creatine kinase - Adverse effects; Polymorphism, Genetic - Adverse effects; Hydroxymethylglutaryl-CoA Reductase Inhibitors - Adverse effects
• Online Access: http://psasir.upm.edu.my/id/eprint/99069/1/FPSK%20%28m%29%202016%2037%20IR.pdf; http://psasir.upm.edu.my/id/eprint/99069/

Background: Statin, a first line treatment for dyslipidaemia has reduced patient compliance and is underprescribed because of its side effect of muscle toxicity. The incidence of statin-induced muscle toxicity ranges from 1% to 7%, whereas severe muscle toxicity occurs in up to 0.5% of patients. In...